Molecular and phylogenetic analyses of influenza B viruses isolated from pediatric inpatients in South Korea during the 2011–2012 winter season

Jeong Hyun Nam; Eun Jung Song; Daesub Song; Erica Españo; Sang Mu Shim; Seo Hee Jeong; Robert G. Webster; Woo Joo Kim; Jeong Ki Kim

doi:10.1099/jgv.0.000983

Molecular and phylogenetic analyses of influenza B viruses isolated from pediatric inpatients in South Korea during the 2011–2012 winter season

Jeong Hyun Nam, Eun Jung Song, Daesub Song, Erica Españo, Sang Mu Shim, Seo Hee Jeong, Robert G. Webster, Woo Joo Kim, Jeong Ki Kim

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1 Citation (Scopus)

Abstract

Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011–2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein.

Original language	English
Article number	000983
Pages (from-to)	2950-2954
Number of pages	5
Journal	Journal of General Virology
Volume	98
Issue number	12
DOIs	https://doi.org/10.1099/jgv.0.000983
Publication status	Published - 2017 Dec

Bibliographical note

Funding Information:
This work was supported by the Korea Institute for Planning and Evaluation of Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Animal Disease Management Technology Development Program funded by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (Grant no. 316042-03-2-HD020) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant no. HD16A1487 and A103001).

Publisher Copyright:
© 2017 The Authors.

Keywords

Influenza B virus
Molecular characterization
Phylogenetic analysis

ASJC Scopus subject areas

Virology

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10.1099/jgv.0.000983

Cite this

Nam, J. H., Song, E. J., Song, D., Españo, E., Shim, S. M., Jeong, S. H., Webster, R. G., Kim, W. J., & Kim, J. K. (2017). Molecular and phylogenetic analyses of influenza B viruses isolated from pediatric inpatients in South Korea during the 2011–2012 winter season. Journal of General Virology, 98(12), 2950-2954. Article 000983. https://doi.org/10.1099/jgv.0.000983

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abstract = "Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011–2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein.",

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note = "Funding Information: This work was supported by the Korea Institute for Planning and Evaluation of Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Animal Disease Management Technology Development Program funded by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (Grant no. 316042-03-2-HD020) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant no. HD16A1487 and A103001). Publisher Copyright: {\textcopyright} 2017 The Authors.",

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AU - Shim, Sang Mu

AU - Jeong, Seo Hee

AU - Webster, Robert G.

AU - Kim, Woo Joo

AU - Kim, Jeong Ki

N1 - Funding Information: This work was supported by the Korea Institute for Planning and Evaluation of Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Animal Disease Management Technology Development Program funded by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (Grant no. 316042-03-2-HD020) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant no. HD16A1487 and A103001). Publisher Copyright: © 2017 The Authors.

PY - 2017/12

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N2 - Influenza B virus remains a major cause of respiratory diseases worldwide. Because of limited epidemiological and genetic data, the local and global transmission patterns of influenza B virus are not fully understood. Here we report the molecular and phylogenetic characterization of 163 influenza B virus isolates from pediatric inpatients with influenza-like illness in the winter of 2011–2012 in South Korea. Analysis of haemagglutinin and neuraminidase genes of the influenza B isolates revealed that both B/Victoria (62 %) and B/Yamagata lineages (38 %) co-circulated during that influenza season, and a considerable number of the isolates carried several amino acid substitutions in the four major antigenic epitopes of their haemagglutinin protein.

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Molecular and phylogenetic analyses of influenza B viruses isolated from pediatric inpatients in South Korea during the 2011–2012 winter season

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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