Abstract
The nucleotide sequence of a 876 bp region in E. coli chromosome that encodes Ecotin was determined. The proposed coding sequence for Ecotin is 486 nucleotides long, which would encode a protein consisting of 162 amino acids with a calculated molecular weight of 18 192 Da. The deduced primary sequence of Ecotin includes a 20-residue signal sequence, cleavage of which would give rise to a mature protein with a molecular weight of 16 099 Da. Ecotin does not contain any consensus reactive site sequences of known serine protease inhibitor families, suggesting that Ecotin is a novel inhibitor.
Original language | English |
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Pages (from-to) | 53-56 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 287 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1991 Aug 5 |
Externally published | Yes |
Keywords
- Ecotin
- Protease inhibitor
- Signal sequence
- eti gene
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology