Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Hyo Min Cho; Woong Sun

doi:10.1038/s12276-020-0434-9

Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Hyo Min Cho, Woong Sun

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.

Original language	English
Pages (from-to)	730-737
Number of pages	8
Journal	Experimental and Molecular Medicine
Volume	52
Issue number	5
DOIs	https://doi.org/10.1038/s12276-020-0434-9
Publication status	Published - 2020 May 1

Bibliographical note

Funding Information:
This research was supported by the Brain Research Program through the National Research Foundation (NRF) funded by the Korean Ministry of Science, ICT & Future Planning (NRF-2015M3C7A1028790, NRF-2017M3A9B3061308, and NRF-2018R1A2A3075271).

Publisher Copyright:
© 2020, The Author(s).

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s12276-020-0434-9

Cite this

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abstract = "Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.",

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AU - Cho, Hyo Min

AU - Sun, Woong

N1 - Funding Information: This research was supported by the Brain Research Program through the National Research Foundation (NRF) funded by the Korean Ministry of Science, ICT & Future Planning (NRF-2015M3C7A1028790, NRF-2017M3A9B3061308, and NRF-2018R1A2A3075271). Publisher Copyright: © 2020, The Author(s).

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N2 - Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.

AB - Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.

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ER -

Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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