Molecular diagnosis of infectious diseases for ponit- of-care using DNA hydrogel based repid kit

Hwang Soo Kim, Ho Yoon Lee, Chan Hee Park, Hyun Sung Kim, Young Joon Kim, Jin A. Choi, Se Hyun Shin

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Among patients with virus-like symptoms such as high fever and inflammatory symptoms in the field, it is necessary to quickly verify and seclude a patient with high-risk virus infections. This research introduces a new method of microfluidic to detect various kinds of virus using isothermal amplification technique on a lot of microbead surfaces packaged in microtube. Amplification reaction named the rolling circle amplification (RCA) is adopted to examine patients in this field. The amplified products forms a DNA hydrogel by forming a dumbbell-type probe through the complementary target RCA of the microfluid channel[1, 2].

    Original languageEnglish
    Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
    PublisherChemical and Biological Microsystems Society
    Pages843-844
    Number of pages2
    ISBN (Electronic)9781733419000
    Publication statusPublished - 2019
    Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
    Duration: 2019 Oct 272019 Oct 31

    Publication series

    Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

    Conference

    Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
    Country/TerritorySwitzerland
    CityBasel
    Period19/10/2719/10/31

    Bibliographical note

    Funding Information:
    This research was supported by a National Research Foundation of Korea (NRF) Grant funded by the Korean Government, MSIP (NRF-2016R1A5A1010148) and the Bio & Medical Technology Development Program of the NRF, funded by the Korean government, MSIP (NRF-2015M3A9D7031015).

    Publisher Copyright:
    © 2019 CBMS-0001.

    Keywords

    • DNA hydrogel
    • Microfluidics
    • POCT
    • Rolling Circle Amplification (RCA)

    ASJC Scopus subject areas

    • Bioengineering
    • Chemical Engineering (miscellaneous)

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