Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation

Arnold J. Heynen; Bong June Yoon; Cheng Hang Liu; Hee J. Chung; Richard L. Huganir; Mark F. Bear

doi:10.1038/nn1100

Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation

Arnold J. Heynen, Bong June Yoon, Cheng Hang Liu, Hee J. Chung, Richard L. Huganir, Mark F. Bear

Research output: Contribution to journal › Article › peer-review

271 Citations (Scopus)

Abstract

A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity.

Original language	English
Pages (from-to)	854-862
Number of pages	9
Journal	Nature Neuroscience
Volume	6
Issue number	8
DOIs	https://doi.org/10.1038/nn1100
Publication status	Published - 2003 Aug 1
Externally published	Yes

Bibliographical note

Funding Information:
We thank C. Orsini from the laboratory of L. Maffei (Pisa, Italy) for providing VEP software, and E. Sklar, K. Clayton, K. Miller and S. Meagher for assistance. The work was funded by the Howard Hughes Medical Institute and the National Eye Institute.

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nn1100

Cite this

@article{42c4e3a25ecd46b0b566d7cc628c6de3,

title = "Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation",

abstract = "A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity.",

author = "Heynen, {Arnold J.} and Yoon, {Bong June} and Liu, {Cheng Hang} and Chung, {Hee J.} and Huganir, {Richard L.} and Bear, {Mark F.}",

note = "Funding Information: We thank C. Orsini from the laboratory of L. Maffei (Pisa, Italy) for providing VEP software, and E. Sklar, K. Clayton, K. Miller and S. Meagher for assistance. The work was funded by the Howard Hughes Medical Institute and the National Eye Institute.",

year = "2003",

month = aug,

day = "1",

doi = "10.1038/nn1100",

language = "English",

volume = "6",

pages = "854--862",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "8",

}

TY - JOUR

T1 - Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation

AU - Heynen, Arnold J.

AU - Yoon, Bong June

AU - Liu, Cheng Hang

AU - Chung, Hee J.

AU - Huganir, Richard L.

AU - Bear, Mark F.

N1 - Funding Information: We thank C. Orsini from the laboratory of L. Maffei (Pisa, Italy) for providing VEP software, and E. Sklar, K. Clayton, K. Miller and S. Meagher for assistance. The work was funded by the Howard Hughes Medical Institute and the National Eye Institute.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity.

AB - A dramatic form of experience-dependent synaptic plasticity is revealed in visual cortex when one eye is temporarily deprived of vision during early postnatal life. Monocular deprivation (MD) alters synaptic transmission such that cortical neurons cease to respond to stimulation of the deprived eye, but how this occurs is poorly understood. Here we show in rat visual cortex that brief MD sets in motion the same molecular and functional changes as the experimental model of homosynaptic long-term depression (LTD), and that prior synaptic depression by MD occludes subsequent induction of LTD. The mechanisms of LTD, about which there is now a detailed understanding, therefore contribute to visual cortical plasticity.

UR - http://www.scopus.com/inward/record.url?scp=0042031484&partnerID=8YFLogxK

U2 - 10.1038/nn1100

DO - 10.1038/nn1100

M3 - Article

C2 - 12886226

AN - SCOPUS:0042031484

SN - 1097-6256

VL - 6

SP - 854

EP - 862

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 8

ER -

Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this