Molecular mechanisms of cutaneous inflammatory disorder: Atopic dermatitis

Jung Eun Kim, Jong Sic Kim, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalReview articlepeer-review

91 Citations (Scopus)


Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly understood, and the treatment of recalcitrant AD is still challenging. There is accumulating evidence for new gene polymorphisms related to the epidermal barrier function and innate and adaptive immunity in patients with AD. Newly-found T cells and dendritic cell subsets, cytokines, chemokines and signaling pathways have extended our understanding of the molecular pathomechanism underlying AD. Genetic changes caused by environmental factors have been shown to contribute to the pathogenesis of AD. We herein present a review of the genetics, epigenetics, barrier dysfunction and immunological abnormalities in AD with a focus on updated molecular biology.

Original languageEnglish
Article number1234
JournalInternational journal of molecular sciences
Issue number8
Publication statusPublished - 2016 Aug
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research program and Creative Materials Discovery Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science and Technology and the Ministry of Science, ICT and Future Planning (2015R1C1A2A01055073, 2016M3D1A1021387). We also thank Yujin Jung for help in preparation of the revised paper.

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.


  • Atopic dermatitis
  • Barrier
  • Epigenomics
  • Genetics
  • Immunologic abnormalities

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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