Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception

Yongwoo Jang, Minseok Kim, Sun Wook Hwang

Research output: Contribution to journalReview articlepeer-review

136 Citations (Scopus)


Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation. Peripheral tissues undergo many forms of diseases that are frequently accompanied by inflammation. The somatosensory nerves innervating the inflamed areas experience heightened excitability and generate and transmit pain signals. Extensive studies have been carried out to elucidate how prostaglandins play their roles for such signaling at the cellular and molecular levels. Here, we briefly summarize the roles of arachidonic acid-derived prostaglandins, focusing on four prostaglandins and one thromboxane, particularly in terms of their actions on afferent nociceptors. We discuss the biosynthesis of the prostaglandins, their specific action sites, the pathological alteration of the expression levels of related proteins, the neuronal outcomes of receptor stimulation, their correlation with behavioral nociception, and the pharmacological efficacy of their regulators. This overview will help to a better understanding of the pathological roles that prostaglandins play in the somatosensory system and to a finding of critical molecular contributors to normalizing pain.

Original languageEnglish
Article number30
JournalJournal of Neuroinflammation
Issue number1
Publication statusPublished - 2020 Jan 22

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).


  • DRG neuron
  • Inflammation
  • Pain
  • Prostaglandin
  • Signal transduction

ASJC Scopus subject areas

  • General Neuroscience
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience


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