Molecular modeling of 3-arylisoquinoline antitumor agents active against A-549. A comparative molecular field analysis study

Keyphrases

• A549 100%
• 3-Arylisoquinoline 100%
• Molecular Modeling 100%
• Antitumor Agents 100%
• Comparative Molecular Field Analysis (CoMFA) 100%
• Isoquinoline 66%
• Aryl Rings 66%
• Analysis Program 33%
• X-ray Crystal Structure 33%
• Quantitative Structure-activity Relationship 33%
• Tumor Cytotoxicity 33%
• Dihedral Angle 33%
• R2 Value 33%
• Molecular Modeling Studies 33%
• Human Lung Tumors 33%
• Pharmacophore Model 33%
• Bioisostere 33%
• Benzophenanthridine Alkaloids 33%
• Single X-ray 33%
• Lung Tumor Cells 33%
• Conformational Search 33%
• Phenylisoquinoline 33%

Chemistry

• Isoquinoline 100%
• Antineoplastic Agent 100%
• Molecular Model 100%
• Crystal Structure 50%
• Dihedral Angle 50%
• Antitumor 50%
• QSAR Study 50%
• Benzophenanthridine Alkaloid 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticarcinogen 100%
• Comparative Molecular Field Analysis 100%
• Isoquinoline 66%
• Quantitative Structure-Activity Relationship 33%
• Lung Tumor 33%
• Benzophenanthridine Derivative 33%
• Cytotoxicity 33%
• Quantitative Structure Activity Relation 33%