Molecular networking-based de-replication strategy leads to the isolation of a new chromone from Pleosporales sp.

Haeun Kwon; Jun Gu Kim; Jeong Joo Oh; Jae Jin Kim; Gyu Hyeok Kim; Bang Yeon Hwang; Joung Han Yim; Dongho Lee

doi:10.20307/nps.2020.26.4.340

Molecular networking-based de-replication strategy leads to the isolation of a new chromone from Pleosporales sp.

Haeun Kwon, Jun Gu Kim, Jeong Joo Oh, Jae Jin Kim, Gyu Hyeok Kim, Bang Yeon Hwang, Joung Han Yim, Dongho Lee

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher’s method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC₅₀ value of 118.7 µM.

Original language	English
Pages (from-to)	340-344
Number of pages	5
Journal	Natural Product Sciences
Volume	26
Issue number	4
DOIs	https://doi.org/10.20307/nps.2020.26.4.340
Publication status	Published - 2020

Bibliographical note

Publisher Copyright:
© 2020, Korean Society of Pharmacognosy. All rights reserved.

Keywords

Chromone
Molecular networking
Mosher’s method
Nitric oxide production
Pleosporales sp.

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry

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10.20307/nps.2020.26.4.340

Cite this

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title = "Molecular networking-based de-replication strategy leads to the isolation of a new chromone from Pleosporales sp.",

abstract = "A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher{\textquoteright}s method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 µM.",

keywords = "Chromone, Molecular networking, Mosher{\textquoteright}s method, Nitric oxide production, Pleosporales sp.",

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AU - Kwon, Haeun

AU - Kim, Jun Gu

AU - Oh, Jeong Joo

AU - Kim, Jae Jin

AU - Kim, Gyu Hyeok

AU - Hwang, Bang Yeon

AU - Yim, Joung Han

AU - Lee, Dongho

PY - 2020

Y1 - 2020

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KW - Mosher’s method

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Molecular networking-based de-replication strategy leads to the isolation of a new chromone from Pleosporales sp.

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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