Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam

Se Hun Gu; Burton K. Lim; Blaise Kadjo; Satoru Arai; Jeong Ah Kim; Violaine Nicolas; Aude Lalis; Christiane Denys; Joseph A. Cook; Samuel R. Dominguez; Kathryn V. Holmes; Lela Urushadze; Ketevan Sidamonidze; Davit Putkaradze; Ivan V. Kuzmin; Michael Y. Kosoy; Jin Won Song; Richard Yanagihara

doi:10.3390/v6051897

Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam

Se Hun Gu, Burton K. Lim, Blaise Kadjo, Satoru Arai, Jeong Ah Kim, Violaine Nicolas, Aude Lalis, Christiane Denys, Joseph A. Cook, Samuel R. Dominguez, Kathryn V. Holmes, Lela Urushadze, Ketevan Sidamonidze, Davit Putkaradze, Ivan V. Kuzmin, Michael Y. Kosoy, Jin Won Song, Richard Yanagihara

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles prompted a further exploration of their host diversification by analyzing frozen, ethanol-fixed and RNAlater®-preserved archival tissues and fecal samples from 533 bats (representing seven families, 28 genera and 53 species in the order Chiroptera), captured in Asia, Africa and the Americas in 1981-2012, using RT-PCR. Hantavirus RNA was detected in Pomona roundleaf bats (Hipposideros pomona) (family Hipposideridae), captured in Vietnam in 1997 and 1999, and in banana pipistrelles (Neoromicia nanus) (family Vespertilionidae), captured in Côte d'Ivoire in 2011. Phylogenetic analysis, based on the full-length S- and partial M- and L-segment sequences using maximum likelihood and Bayesian methods, demonstrated that the newfound hantaviruses formed highly divergent lineages, comprising other recently recognized bat-borne hantaviruses in Sierra Leone and China. The detection of bat-associated hantaviruses opens a new era in hantavirology and provides insights into their evolutionary origins.

Original language	English
Pages (from-to)	1897-1910
Number of pages	14
Journal	Viruses
Volume	6
Issue number	5
DOIs	https://doi.org/10.3390/v6051897
Publication status	Published - 2014 Apr 29

Keywords

Chiroptera
Evolution
Hantavirus

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v6051897

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Gu, S. H., Lim, B. K., Kadjo, B., Arai, S., Kim, J. A., Nicolas, V., Lalis, A., Denys, C., Cook, J. A., Dominguez, S. R., Holmes, K. V., Urushadze, L., Sidamonidze, K., Putkaradze, D., Kuzmin, I. V., Kosoy, M. Y., Song, J. W., & Yanagihara, R. (2014). Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses, 6(5), 1897-1910. https://doi.org/10.3390/v6051897

Gu, SH, Lim, BK, Kadjo, B, Arai, S, Kim, JA, Nicolas, V, Lalis, A, Denys, C, Cook, JA, Dominguez, SR, Holmes, KV, Urushadze, L, Sidamonidze, K, Putkaradze, D, Kuzmin, IV, Kosoy, MY, Song, JW & Yanagihara, R 2014, 'Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam', Viruses, vol. 6, no. 5, pp. 1897-1910. https://doi.org/10.3390/v6051897

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abstract = "The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles prompted a further exploration of their host diversification by analyzing frozen, ethanol-fixed and RNAlater{\textregistered}-preserved archival tissues and fecal samples from 533 bats (representing seven families, 28 genera and 53 species in the order Chiroptera), captured in Asia, Africa and the Americas in 1981-2012, using RT-PCR. Hantavirus RNA was detected in Pomona roundleaf bats (Hipposideros pomona) (family Hipposideridae), captured in Vietnam in 1997 and 1999, and in banana pipistrelles (Neoromicia nanus) (family Vespertilionidae), captured in C{\^o}te d'Ivoire in 2011. Phylogenetic analysis, based on the full-length S- and partial M- and L-segment sequences using maximum likelihood and Bayesian methods, demonstrated that the newfound hantaviruses formed highly divergent lineages, comprising other recently recognized bat-borne hantaviruses in Sierra Leone and China. The detection of bat-associated hantaviruses opens a new era in hantavirology and provides insights into their evolutionary origins.",

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AU - Kim, Jeong Ah

AU - Nicolas, Violaine

AU - Lalis, Aude

AU - Denys, Christiane

AU - Cook, Joseph A.

AU - Dominguez, Samuel R.

AU - Holmes, Kathryn V.

AU - Urushadze, Lela

AU - Sidamonidze, Ketevan

AU - Putkaradze, Davit

AU - Kuzmin, Ivan V.

AU - Kosoy, Michael Y.

AU - Song, Jin Won

AU - Yanagihara, Richard

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AB - The recent discovery of genetically distinct hantaviruses in multiple species of shrews and moles prompted a further exploration of their host diversification by analyzing frozen, ethanol-fixed and RNAlater®-preserved archival tissues and fecal samples from 533 bats (representing seven families, 28 genera and 53 species in the order Chiroptera), captured in Asia, Africa and the Americas in 1981-2012, using RT-PCR. Hantavirus RNA was detected in Pomona roundleaf bats (Hipposideros pomona) (family Hipposideridae), captured in Vietnam in 1997 and 1999, and in banana pipistrelles (Neoromicia nanus) (family Vespertilionidae), captured in Côte d'Ivoire in 2011. Phylogenetic analysis, based on the full-length S- and partial M- and L-segment sequences using maximum likelihood and Bayesian methods, demonstrated that the newfound hantaviruses formed highly divergent lineages, comprising other recently recognized bat-borne hantaviruses in Sierra Leone and China. The detection of bat-associated hantaviruses opens a new era in hantavirology and provides insights into their evolutionary origins.

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KW - Hantavirus

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Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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