Molecular sensing for biomarkers of invasive cancer cells using localized surface plasmon resonance

Yoochan Hong, Minhee Ku, Jin Suck Suh, Yong Min Huh, Dae Sung Yoon, Jaemoon Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this study, we describe the development of cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance (LSPR) that enabling recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of sensing chip was confirmed using various solvents that having different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto surface of GNRs and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from invasive cancer cells.

Original languageEnglish
Title of host publicationNano-Bio Sensing, Imaging, and Spectroscopy
Publication statusPublished - 2013
Externally publishedYes
EventSPIE Nano-Bio Sensing, Imaging, and Spectroscopy - Jeju, Korea, Republic of
Duration: 2013 Feb 202013 Feb 23

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceSPIE Nano-Bio Sensing, Imaging, and Spectroscopy
Country/TerritoryKorea, Republic of


  • LSPR
  • MT1-MMP
  • biomarker
  • cancer
  • enzyme
  • molecular sensing
  • nanobiosensor
  • nanoparticle

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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