Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

Ji Hae Lee; Boram Cho; Hee jin Jun; Woo Duck Seo; Dong Woo Kim; Kang Jin Cho; Sung Joon Lee

doi:10.1007/s10529-011-0838-7

Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

Ji Hae Lee, Boram Cho, Hee jin Jun, Woo Duck Seo, Dong Woo Kim, Kang Jin Cho, Sung Joon Lee

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.

Original language	English
Pages (from-to)	805-812
Number of pages	8
Journal	Biotechnology letters
Volume	34
Issue number	5
DOIs	https://doi.org/10.1007/s10529-011-0838-7
Publication status	Published - 2012 May

Bibliographical note

Funding Information:
Acknowledgment This work was carried out with the support of ‘‘Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ007480)’’ Rural Development Administration, Republic of Korea.

Keywords

Melanogenesis
Momilactone B
Protein kinase A
Tyrosinase

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1007/s10529-011-0838-7

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title = "Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes",

abstract = "Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.",

keywords = "Melanogenesis, Momilactone B, Protein kinase A, Tyrosinase",

author = "Lee, {Ji Hae} and Boram Cho and Jun, {Hee jin} and Seo, {Woo Duck} and Kim, {Dong Woo} and Cho, {Kang Jin} and Lee, {Sung Joon}",

note = "Funding Information: Acknowledgment This work was carried out with the support of {\textquoteleft}{\textquoteleft}Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ007480){\textquoteright}{\textquoteright} Rural Development Administration, Republic of Korea.",

year = "2012",

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doi = "10.1007/s10529-011-0838-7",

language = "English",

volume = "34",

pages = "805--812",

journal = "Biotechnology letters",

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TY - JOUR

T1 - Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

AU - Lee, Ji Hae

AU - Cho, Boram

AU - Jun, Hee jin

AU - Seo, Woo Duck

AU - Kim, Dong Woo

AU - Cho, Kang Jin

AU - Lee, Sung Joon

N1 - Funding Information: Acknowledgment This work was carried out with the support of ‘‘Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ007480)’’ Rural Development Administration, Republic of Korea.

PY - 2012/5

Y1 - 2012/5

N2 - Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.

AB - Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.

KW - Melanogenesis

KW - Momilactone B

KW - Protein kinase A

KW - Tyrosinase

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U2 - 10.1007/s10529-011-0838-7

DO - 10.1007/s10529-011-0838-7

M3 - Article

C2 - 22215377

AN - SCOPUS:84860888432

SN - 0141-5492

VL - 34

SP - 805

EP - 812

JO - Biotechnology letters

JF - Biotechnology letters

IS - 5

ER -

Momilactione B inhibits protein kinase A signaling and reduces tyrosinase-related proteins 1 and 2 expression in melanocytes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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