Abstract
Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
Original language | English |
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Pages (from-to) | 13267-13270 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 88 |
DOIs | |
Publication status | Published - 2019 |
Bibliographical note
Funding Information:This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.), and the Basic Science Research Program (2017R1D1A1-B03030062, M. W.) funded by the Ministry of Education. This work was also supported in part by Korea Basic Science Institute Grant (T38662).
Publisher Copyright:
© 2019 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- Chemistry(all)
- Catalysis