Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Won Young Kim; Miae Won; Abbas Salimi; Amit Sharma; Jong Hyeon Lim; Seung Hae Kwon; Joo Yeong Jeon; Jin Yong Lee; Jong Seung Kim

doi:10.1039/c9cc07009e

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Won Young Kim, Miae Won, Abbas Salimi, Amit Sharma, Jong Hyeon Lim, Seung Hae Kwon, Joo Yeong Jeon, Jin Yong Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Original language	English
Pages (from-to)	13267-13270
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	88
DOIs	https://doi.org/10.1039/c9cc07009e
Publication status	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c9cc07009e

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@article{78e2e11300494a2c8f7df34436a1a943,

title = "Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis",

abstract = "Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.",

author = "Kim, {Won Young} and Miae Won and Abbas Salimi and Amit Sharma and Lim, {Jong Hyeon} and Kwon, {Seung Hae} and Jeon, {Joo Yeong} and Lee, {Jin Yong} and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.), and the Basic Science Research Program (2017R1D1A1-B03030062, M. W.) funded by the Ministry of Education. This work was also supported in part by Korea Basic Science Institute Grant (T38662). Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9cc07009e",

language = "English",

volume = "55",

pages = "13267--13270",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "88",

}

TY - JOUR

T1 - Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

AU - Kim, Won Young

AU - Won, Miae

AU - Salimi, Abbas

AU - Sharma, Amit

AU - Lim, Jong Hyeon

AU - Kwon, Seung Hae

AU - Jeon, Joo Yeong

AU - Lee, Jin Yong

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.), and the Basic Science Research Program (2017R1D1A1-B03030062, M. W.) funded by the Ministry of Education. This work was also supported in part by Korea Basic Science Institute Grant (T38662). Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

AB - Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

UR - http://www.scopus.com/inward/record.url?scp=85074306673&partnerID=8YFLogxK

U2 - 10.1039/c9cc07009e

DO - 10.1039/c9cc07009e

M3 - Article

C2 - 31621760

AN - SCOPUS:85074306673

SN - 1359-7345

VL - 55

SP - 13267

EP - 13270

JO - Chemical Communications

JF - Chemical Communications

IS - 88

ER -

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Abstract

ASJC Scopus subject areas

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