Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

Won Young Kim, Miae Won, Abbas Salimi, Amit Sharma, Jong Hyeon Lim, Seung Hae Kwon, Joo Yeong Jeon, Jin Yong Lee, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Original languageEnglish
Pages (from-to)13267-13270
Number of pages4
JournalChemical Communications
Issue number88
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702 and NRF-2019M3E5D1A01068998, J. S. K.), and the Basic Science Research Program (2017R1D1A1-B03030062, M. W.) funded by the Ministry of Education. This work was also supported in part by Korea Basic Science Institute Grant (T38662).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis


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