Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Hua Han Xiang; Su Hong Seong; Sang Hwang Ji; Hwa Jeong Seon; Hye Hwang Ji; Hee Lee Min; Koo Lee Myung; Dongho Lee; Seup Ro Jai; Yeon Hwang Bang

doi:10.1007/bf02977895

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hwa Jeong Seon, Hye Hwang Ji, Hee Lee Min, Koo Lee Myung, Dongho Lee, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC₅₀ values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC₅₀ 0.8 μM) than MAO-A (IC₅₀ >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

Original language	English
Pages (from-to)	1324-1327
Number of pages	4
Journal	Archives of pharmacal research
Volume	28
Issue number	12
DOIs	https://doi.org/10.1007/bf02977895
Publication status	Published - 2005 Dec
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a Chungbuk National University Grant in 2004. We are grateful to Korea Basic Science Institute for 1Hand 13C-NMR spectral measurements.

Keywords

Cudrania tricuspidata
Gancaonin A
Monoamine oxidase inhibitor
Moraceae
Prenylated isoflavone

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/bf02977895

Cite this

@article{b6ca8217bf504449bf0b858114576a83,

title = "Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata",

abstract = "A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.",

keywords = "Cudrania tricuspidata, Gancaonin A, Monoamine oxidase inhibitor, Moraceae, Prenylated isoflavone",

author = "Xiang, {Hua Han} and Seong, {Su Hong} and Ji, {Sang Hwang} and Seon, {Hwa Jeong} and Ji, {Hye Hwang} and Min, {Hee Lee} and Myung, {Koo Lee} and Dongho Lee and Jai, {Seup Ro} and Bang, {Yeon Hwang}",

note = "Funding Information: This work was supported by a Chungbuk National University Grant in 2004. We are grateful to Korea Basic Science Institute for 1Hand 13C-NMR spectral measurements.",

year = "2005",

month = dec,

doi = "10.1007/bf02977895",

language = "English",

volume = "28",

pages = "1324--1327",

journal = "Archives of pharmacal research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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T1 - Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

AU - Xiang, Hua Han

AU - Seong, Su Hong

AU - Ji, Sang Hwang

AU - Seon, Hwa Jeong

AU - Ji, Hye Hwang

AU - Min, Hee Lee

AU - Myung, Koo Lee

AU - Lee, Dongho

AU - Jai, Seup Ro

AU - Bang, Yeon Hwang

N1 - Funding Information: This work was supported by a Chungbuk National University Grant in 2004. We are grateful to Korea Basic Science Institute for 1Hand 13C-NMR spectral measurements.

PY - 2005/12

Y1 - 2005/12

N2 - A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

AB - A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

KW - Cudrania tricuspidata

KW - Gancaonin A

KW - Monoamine oxidase inhibitor

KW - Moraceae

KW - Prenylated isoflavone

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DO - 10.1007/bf02977895

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AN - SCOPUS:29944447056

SN - 0253-6269

VL - 28

SP - 1324

EP - 1327

JO - Archives of pharmacal research

JF - Archives of pharmacal research

IS - 12

ER -

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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