Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus

Hwa Jeong Seon; Hua Han Xiang; Su Hong Seong; Sang Hwang Ji; Hye Hwang Ji; Dongho Lee; Koo Lee Myung; Seup Ro Jai; Yeon Hwang Bang

doi:10.1007/bf02969302

Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus

Hwa Jeong Seon, Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hye Hwang Ji, Dongho Lee, Koo Lee Myung, Seup Ro Jai, Yeon Hwang Bang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC₅₀ values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC₅₀ 0.5 and 0.6 μM, respectively) compared to MAO-A (IC₅₀ 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

Original language	English
Pages (from-to)	1119-1124
Number of pages	6
Journal	Archives of pharmacal research
Volume	29
Issue number	12
DOIs	https://doi.org/10.1007/bf02969302
Publication status	Published - 2006 Dec 31

Keywords

Coumarin
Dictamnus albus
Monoamine oxidase inhibitor
Rutaceae

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/bf02969302

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@article{b506257ae463463e9032afa8ad97e0bc,

title = "Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus",

abstract = "The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.",

keywords = "Coumarin, Dictamnus albus, Monoamine oxidase inhibitor, Rutaceae",

author = "Seon, {Hwa Jeong} and Xiang, {Hua Han} and Seong, {Su Hong} and Ji, {Sang Hwang} and Ji, {Hye Hwang} and Dongho Lee and Myung, {Koo Lee} and Jai, {Seup Ro} and Bang, {Yeon Hwang}",

year = "2006",

month = dec,

day = "31",

doi = "10.1007/bf02969302",

language = "English",

volume = "29",

pages = "1119--1124",

journal = "Archives of Pharmacal Research",

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AU - Seon, Hwa Jeong

AU - Xiang, Hua Han

AU - Seong, Su Hong

AU - Ji, Sang Hwang

AU - Ji, Hye Hwang

AU - Lee, Dongho

AU - Myung, Koo Lee

AU - Jai, Seup Ro

AU - Bang, Yeon Hwang

PY - 2006/12/31

Y1 - 2006/12/31

N2 - The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

AB - The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

KW - Coumarin

KW - Dictamnus albus

KW - Monoamine oxidase inhibitor

KW - Rutaceae

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JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 12

ER -

Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus

Abstract

Keywords

ASJC Scopus subject areas

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