Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus

Hwa Jeong Seon, Hua Han Xiang, Su Hong Seong, Sang Hwang Ji, Hye Hwang Ji, Dongho Lee, Koo Lee Myung, Seup Ro Jai, Yeon Hwang Bang

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R- hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalArchives of pharmacal research
Issue number12
Publication statusPublished - 2006 Dec 31


  • Coumarin
  • Dictamnus albus
  • Monoamine oxidase inhibitor
  • Rutaceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus'. Together they form a unique fingerprint.

Cite this