Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

Xiang Hua Han; Ji Hye Hwang; Seong Su Hong; Sanggil Choe; Chul Lee; Moon Soon Lee; Dongho Lee; Myung Koo Lee; Mi Kyeong Lee; Bang Yeon Hwang

Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

Xiang Hua Han, Ji Hye Hwang, Seong Su Hong, Sanggil Choe, Chul Lee, Moon Soon Lee, Dongho Lee, Myung Koo Lee, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC₅₀ values of 82.3, 30.8, and 71.8 μM, respectively.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Natural Product Sciences
Volume	16
Issue number	2
Publication status	Published - 2010 Jun

Keywords

Benzylated flavonoid
Cudrania tricuspidata
Monoamine oxidase inhibitor
Moraceae

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry

Cite this

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title = "Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata",

abstract = "Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.",

keywords = "Benzylated flavonoid, Cudrania tricuspidata, Monoamine oxidase inhibitor, Moraceae",

author = "Han, {Xiang Hua} and Hwang, {Ji Hye} and Hong, {Seong Su} and Sanggil Choe and Chul Lee and Lee, {Moon Soon} and Dongho Lee and Lee, {Myung Koo} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

year = "2010",

month = jun,

language = "English",

volume = "16",

pages = "75--79",

journal = "Natural Product Sciences",

issn = "1226-3907",

publisher = "Korean Society of Pharmacognosy",

number = "2",

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TY - JOUR

T1 - Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

AU - Han, Xiang Hua

AU - Hwang, Ji Hye

AU - Hong, Seong Su

AU - Choe, Sanggil

AU - Lee, Chul

AU - Lee, Moon Soon

AU - Lee, Dongho

AU - Lee, Myung Koo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2010/6

Y1 - 2010/6

N2 - Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.

AB - Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.

KW - Benzylated flavonoid

KW - Cudrania tricuspidata

KW - Monoamine oxidase inhibitor

KW - Moraceae

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M3 - Article

AN - SCOPUS:79954989655

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VL - 16

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ER -

Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata

Abstract

Keywords

ASJC Scopus subject areas

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