Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

Jin Woong Lee; Byoungsang Lee; Cheol Hyun Park; Jun Hyuk Heo; Tae Yoon Lee; Dongtak Lee; Jina Bae; Priyannth Ramasami Sundharbaabu; Won Kyun Yeom; Sudong Chae; Jae Hyuk Lim; Seok Won Lee; Jin Seok Choi; Hyung Bin Bae; Jae Young Choi; Eun Ho Lee; Dae Sung Yoon; Geun Young Yeom; Hyunjung Shin; Jung Heon Lee

doi:10.1002/adma.202406179

Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

Jin Woong Lee
, Byoungsang Lee
, Cheol Hyun Park
, Jun Hyuk Heo^*
, Tae Yoon Lee
, Dongtak Lee
, Jina Bae
, Priyannth Ramasami Sundharbaabu
, Won Kyun Yeom
, Sudong Chae
, Jae Hyuk Lim
, Seok Won Lee
, Jin Seok Choi
, Hyung Bin Bae
, Jae Young Choi
, Eun Ho Lee
, Dae Sung Yoon
, Geun Young Yeom
, Hyunjung Shin
, Jung Heon Lee^*

^*Corresponding author for this work

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA₁Ca_2.2(PO₄)_1.3OH_2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.

Original language	English
Article number	2406179
Journal	Advanced Materials
Volume	36
Issue number	41
DOIs	https://doi.org/10.1002/adma.202406179
Publication status	Published - 2024 Oct 10

Bibliographical note

Publisher Copyright:
© 2024 Wiley-VCH GmbH.

Keywords

DNA
DNApatite
bone mimicking structure
elastic apatite
organo–inorganic structure
sub-nanometer nacre mimetic architecture

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.202406179

Cite this

Lee, J. W., Lee, B., Park, C. H., Heo, J. H., Lee, T. Y., Lee, D., Bae, J., Sundharbaabu, P. R., Yeom, W. K., Chae, S., Lim, J. H., Lee, S. W., Choi, J. S., Bae, H. B., Choi, J. Y., Lee, E. H., Yoon, D. S., Yeom, G. Y., Shin, H., & Lee, J. H. (2024). Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures. Advanced Materials, 36(41), Article 2406179. https://doi.org/10.1002/adma.202406179

Lee, JW, Lee, B, Park, CH, Heo, JH, Lee, TY, Lee, D, Bae, J, Sundharbaabu, PR, Yeom, WK, Chae, S, Lim, JH, Lee, SW, Choi, JS, Bae, HB, Choi, JY, Lee, EH, Yoon, DS, Yeom, GY, Shin, H & Lee, JH 2024, 'Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures', Advanced Materials, vol. 36, no. 41, 2406179. https://doi.org/10.1002/adma.202406179

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abstract = "Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.",

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AU - Lim, Jae Hyuk

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AU - Choi, Jin Seok

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AU - Choi, Jae Young

AU - Lee, Eun Ho

AU - Yoon, Dae Sung

AU - Yeom, Geun Young

AU - Shin, Hyunjung

AU - Lee, Jung Heon

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AB - Hydroxyapatite (HA) exhibits outstanding biocompatibility, bioactivity, osteoconductivity, and natural anti-inflammatory properties. Pure HA, ion-doped HA, and HA-polymer composites are investigated, but critical limitations such as brittleness remain; numerous efforts are being made to address them. Herein, the novel self-crystallization of a polymeric single-stranded deoxyribonucleic acid (ssDNA) without additional phosphate ions for synthesizing deoxyribonucleic apatite (DNApatite) is presented. The synthesized DNApatite, DNA1Ca2.2(PO4)1.3OH2.1, has a repetitive dual phase of inorganic HA crystals and amorphous organic ssDNA at the sub-nm scale, forming nanorods. Its mechanical properties, including toughness and elasticity, are significantly enhanced compared with those of HA nanorod, with a Young's modulus similar to that of natural bone.

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KW - organo–inorganic structure

KW - sub-nanometer nacre mimetic architecture

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Monolithic DNApatite: An Elastic Apatite with Sub-Nanometer Scale Organo–Inorganic Structures

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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