MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS

Sungmin Jang; Seo Yeon Park; So Min Ahn; Soon Young Hwang; Seong Woo Kim; Jaeryung Oh; Cheolmin Yun

doi:10.1097/IAE.0000000000002528

MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS

Sungmin Jang, Seo Yeon Park, So Min Ahn, Soon Young Hwang, Seong Woo Kim, Jaeryung Oh, Cheolmin Yun

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.

Original language	English
Pages (from-to)	686-694
Number of pages	9
Journal	Retina
Volume	40
Issue number	4
DOIs	https://doi.org/10.1097/IAE.0000000000002528
Publication status	Published - 2020 Apr 1

Bibliographical note

Funding Information:
Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033092).

Publisher Copyright:
Copyright © by Ophthalmic Communications Society, Inc

Keywords

Early age-related macular degeneration
Optical coherence tomography
Optical coherence tomography angiography
Retinal pigment epithelium
Subretinal drusenoid deposits

ASJC Scopus subject areas

Ophthalmology

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10.1097/IAE.0000000000002528

Cite this

@article{4b8163a929a743ad853841c40feb3cb3,

title = "MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS",

abstract = "Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.",

keywords = "Early age-related macular degeneration, Optical coherence tomography, Optical coherence tomography angiography, Retinal pigment epithelium, Subretinal drusenoid deposits",

author = "Sungmin Jang and Park, {Seo Yeon} and Ahn, {So Min} and Hwang, {Soon Young} and Kim, {Seong Woo} and Jaeryung Oh and Cheolmin Yun",

note = "Funding Information: Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033092). Publisher Copyright: Copyright {\textcopyright} by Ophthalmic Communications Society, Inc",

year = "2020",

month = apr,

day = "1",

doi = "10.1097/IAE.0000000000002528",

language = "English",

volume = "40",

pages = "686--694",

journal = "Retina",

issn = "0275-004X",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS

AU - Jang, Sungmin

AU - Park, Seo Yeon

AU - Ahn, So Min

AU - Hwang, Soon Young

AU - Kim, Seong Woo

AU - Oh, Jaeryung

AU - Yun, Cheolmin

N1 - Funding Information: Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03033092). Publisher Copyright: Copyright © by Ophthalmic Communications Society, Inc

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.

AB - Purpose: To investigate the features of the retinal pigment epithelium (RPE) on optical coherence tomography in eyes with early age-related macular degeneration with subretinal drusenoid deposit. Methods: We classified the eyes into three types: nonundulating RPE, undulating RPE, and wedge-shaped RPE. We compared the retinal vessel densities, retinal thickness, and choroidal thickness of a 3-mm-diameter zone. Results: We classified 33, 27, and 20 as nonundulating RPE, undulating RPE, and wedge-shaped RPE eyes, respectively. The vascular densities of the superficial and deep capillary plexus showed differences; nonundulating RPE group (23.93 ± 2.26% and 23.54 ± 1.78%), undulating RPE group (22.29 ± 2.80% and 21.94 ± 2.42%), and wedge-shaped RPE group (21.93 ± 2.70% and 20.63 ± 2.42%, P = 0.010 and P, 0.001). The mean retinal thickness and choroidal thickness were also different, nonundulating RPE group (298.26 ± 13.81 μm and 180.08 ± 55.49 μm), undulating RPE group (285.29 ± 21.88 μm and 148.45 ± 55.08 μm), and wedge-shaped RPE group (274.86 ± 20.62 μm and 135.75 ± 39.77 μm) (P = 0.001 and P = 0.007). Conclusion: Altered features of the RPE on optical coherence tomography may indicate advancement in disease and be part of an overall degeneration process in these eyes.

KW - Early age-related macular degeneration

KW - Optical coherence tomography

KW - Optical coherence tomography angiography

KW - Retinal pigment epithelium

KW - Subretinal drusenoid deposits

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U2 - 10.1097/IAE.0000000000002528

DO - 10.1097/IAE.0000000000002528

M3 - Article

C2 - 30950969

AN - SCOPUS:85082561072

SN - 0275-004X

VL - 40

SP - 686

EP - 694

JO - Retina

JF - Retina

IS - 4

ER -

MORPHOLOGIC FEATURES OF THE RETINAL PIGMENT EPITHELIUM AND ASSOCIATED CHORIORETINAL CHARACTERISTICS IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION AND SUBRETINAL DRUSENOID DEPOSITS

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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