MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee; Jane Melissa Lim; Hyunchu Cho; Eunju Kim; Yeonsil Kim; Hye Kyung Oh; Woo Seok Yang; Kyung Hye Roh; Hyun Woo Park; Jung Soon Mo; Je Hyun Yoon; Hyun Kyu Song; Eui Ju Choi

doi:10.1016/j.molcel.2019.01.022

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

In Young Lee
, Jane Melissa Lim
, Hyunchu Cho
, Eunju Kim
, Yeonsil Kim
, Hye Kyung Oh
, Woo Seok Yang
, Kyung Hye Roh
, Hyun Woo Park
, Jung Soon Mo
, Je Hyun Yoon
, Hyun Kyu Song
, Eui Ju Choi^*

^*Corresponding author for this work

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

Original language	English
Pages (from-to)	1138-1149.e6
Journal	Molecular Cell
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.01.022
Publication status	Published - 2019 Mar 21

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

HOIP
LUBAC
MST1
NF-κB
TNFα
TNFα receptor 1 signaling complex
TRAF2
inflammation
macrophage
ubiquitination

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2019.01.022

Cite this

@article{82631f4a3a604b93b14b6e68d0c1a1fc,

title = "MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity",

abstract = "Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.",

keywords = "HOIP, LUBAC, MST1, NF-κB, TNFα, TNFα receptor 1 signaling complex, TRAF2, inflammation, macrophage, ubiquitination",

author = "Lee, \{In Young\} and Lim, \{Jane Melissa\} and Hyunchu Cho and Eunju Kim and Yeonsil Kim and Oh, \{Hye Kyung\} and Yang, \{Woo Seok\} and Roh, \{Kyung Hye\} and Park, \{Hyun Woo\} and Mo, \{Jung Soon\} and Yoon, \{Je Hyun\} and Song, \{Hyun Kyu\} and Choi, \{Eui Ju\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = mar,

day = "21",

doi = "10.1016/j.molcel.2019.01.022",

language = "English",

volume = "73",

pages = "1138--1149.e6",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

AU - Lee, In Young

AU - Lim, Jane Melissa

AU - Cho, Hyunchu

AU - Kim, Eunju

AU - Kim, Yeonsil

AU - Oh, Hye Kyung

AU - Yang, Woo Seok

AU - Roh, Kyung Hye

AU - Park, Hyun Woo

AU - Mo, Jung Soon

AU - Yoon, Je Hyun

AU - Song, Hyun Kyu

AU - Choi, Eui Ju

PY - 2019/3/21

Y1 - 2019/3/21

N2 - Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

AB - Lee et al. identify MST1 as a component of TNF-RSC that phosphorylates HOIP at serine 1,066 and thereby inhibits the linear ubiquitin chain-forming activity of LUBAC in a TRAF2-dependent manner. MST1, by inhibiting an E3 ligase activity of HOIP, negatively regulates the NF-κB-dependent inflammatory gene expression induced by TNFα.

KW - HOIP

KW - LUBAC

KW - MST1

KW - NF-κB

KW - TNFα

KW - TNFα receptor 1 signaling complex

KW - TRAF2

KW - inflammation

KW - macrophage

KW - ubiquitination

UR - https://www.scopus.com/pages/publications/85061189018

U2 - 10.1016/j.molcel.2019.01.022

DO - 10.1016/j.molcel.2019.01.022

M3 - Article

C2 - 30901564

AN - SCOPUS:85061189018

SN - 1097-2765

VL - 73

SP - 1138-1149.e6

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this