Multi-Level Canonical Correlation Analysis for Standard-Dose PET Image Estimation

Le An, Pei Zhang, Ehsan Adeli, Yan Wang, Guangkai Ma, Feng Shi, David S. Lalush, Weili Lin, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Positron emission tomography (PET) images are widely used in many clinical applications, such as tumor detection and brain disorder diagnosis. To obtain PET images of diagnostic quality, a sufficient amount of radioactive tracer has to be injected into a living body, which will inevitably increase the risk of radiation exposure. On the other hand, if the tracer dose is considerably reduced, the quality of the resulting images would be significantly degraded. It is of great interest to estimate a standard-dose PET (S-PET) image from a low-dose one in order to reduce the risk of radiation exposure and preserve image quality. This may be achieved through mapping both S-PET and low-dose PET data into a common space and then performing patch-based sparse representation. However, a one-size-fits-All common space built from all training patches is unlikely to be optimal for each target S-PET patch, which limits the estimation accuracy. In this paper, we propose a data-driven multi-level canonical correlation analysis scheme to solve this problem. In particular, a subset of training data that is most useful in estimating a target S-PET patch is identified in each level, and then used in the next level to update common space and improve estimation. In addition, we also use multi-modal magnetic resonance images to help improve the estimation with complementary information. Validations on phantom and real human brain data sets show that our method effectively estimates S-PET images and well preserves critical clinical quantification measures, such as standard uptake value.

Original languageEnglish
Article number7468470
Pages (from-to)3303-3315
Number of pages13
JournalIEEE Transactions on Image Processing
Issue number7
Publication statusPublished - 2016 Jul

Bibliographical note

Publisher Copyright:
© 1992-2012 IEEE.


  • PET estimation
  • locality-constrained linear coding
  • multi-level CCA
  • multi-modal MRI
  • sparse representation

ASJC Scopus subject areas

  • Software
  • Computer Graphics and Computer-Aided Design


Dive into the research topics of 'Multi-Level Canonical Correlation Analysis for Standard-Dose PET Image Estimation'. Together they form a unique fingerprint.

Cite this