Multifactorial traits of sars-cov-2 cell entry related to diverse host proteases and proteins

Jaehwan You, Jong Hyeon Seok, Myungsoo Joo, Joon Yong Bae, Jin Il Kim, Man Seong Park, Kisoon Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The most effective way to control newly emerging infectious disease, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, is to strengthen preventative or therapeutic public health strategies before the infection spreads worldwide. However, global health systems remain at the early stages in anticipating effective therapeutics or vaccines to combat the SARS-CoV-2 pandemic. While maintaining social distance is the most crucial metric to avoid spreading the virus, symptomatic therapy given to patients on the clinical manifestations helps save lives. The molecular properties of SARS-CoV-2 infection have been quickly elucidated, paving the way to therapeutics, vaccine development, and other medical interventions. Despite this progress, the detailed biomolecular mechanism of SARS-CoV-2 infection remains elusive. Given virus invasion of cells is a determining factor for virulence, understanding the viral entry process can be a mainstay in controlling newly emerged viruses. Since viral entry is mediated by selective cellular proteases or proteins associated with receptors, identification and functional analysis of these proteins could provide a way to disrupt virus propagation. This review comprehensively discusses cellular machinery necessary for SARS-CoV-2 infection. Understanding multifactorial traits of the virus entry will provide a substantial guide to facilitate antiviral drug development.

Original languageEnglish
Pages (from-to)249-262
Number of pages14
JournalBiomolecules and Therapeutics
Issue number3
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This research was supported by the Korea Disease Control and Prevention Agency Program, Grant No. 2020ER533000, and from the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (Grant No. NRF-2017M3A9E4061995).

Publisher Copyright:
© 2021 The Korean Society of Applied Pharmacology.


  • Antiviral drugs
  • Cell entry
  • Cellular proteins
  • SARS-CoV-2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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