Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim; Hwanbum Lee; Keun Sang Oh; Seho Kweon; Ok cheol Jeon; Youngro Byun; Kwangmeyung Kim; Ick Chan Kwon; Sang Yoon Kim; Soon Hong Yuk

doi:10.1016/j.biomaterials.2013.07.040

Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok cheol Jeon, Youngro Byun, Kwangmeyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

Original language	English
Pages (from-to)	8444-8449
Number of pages	6
Journal	Biomaterials
Volume	34
Issue number	33
DOIs	https://doi.org/10.1016/j.biomaterials.2013.07.040
Publication status	Published - 2013 Nov

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).

Keywords

Core/shell nanoparticles
Layer-by-layer approach
Lipid bilayers
Pluronics
Sustained delivery of exenatide

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2013.07.040

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title = "Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus",

abstract = "A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.",

keywords = "Core/shell nanoparticles, Layer-by-layer approach, Lipid bilayers, Pluronics, Sustained delivery of exenatide",

author = "Kim, {Jae Yeon} and Hwanbum Lee and Oh, {Keun Sang} and Seho Kweon and Jeon, {Ok cheol} and Youngro Byun and Kwangmeyung Kim and Kwon, {Ick Chan} and Kim, {Sang Yoon} and Yuk, {Soon Hong}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).",

year = "2013",

month = nov,

doi = "10.1016/j.biomaterials.2013.07.040",

language = "English",

volume = "34",

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T1 - Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

AU - Kim, Jae Yeon

AU - Lee, Hwanbum

AU - Oh, Keun Sang

AU - Kweon, Seho

AU - Jeon, Ok cheol

AU - Byun, Youngro

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

AU - Kim, Sang Yoon

AU - Yuk, Soon Hong

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).

PY - 2013/11

Y1 - 2013/11

N2 - A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

AB - A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

KW - Core/shell nanoparticles

KW - Layer-by-layer approach

KW - Lipid bilayers

KW - Pluronics

KW - Sustained delivery of exenatide

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SN - 0142-9612

VL - 34

SP - 8444

EP - 8449

JO - Biomaterials

JF - Biomaterials

IS - 33

ER -

Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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