Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok cheol Jeon, Youngro Byun, Kwangmeyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

    Original languageEnglish
    Pages (from-to)8444-8449
    Number of pages6
    JournalBiomaterials
    Volume34
    Issue number33
    DOIs
    Publication statusPublished - 2013 Nov

    Bibliographical note

    Funding Information:
    This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).

    Keywords

    • Core/shell nanoparticles
    • Layer-by-layer approach
    • Lipid bilayers
    • Pluronics
    • Sustained delivery of exenatide

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering
    • Ceramics and Composites
    • Biomaterials
    • Mechanics of Materials

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