Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim; Hwanbum Lee; Keun Sang Oh; Seho Kweon; Ok cheol Jeon; Youngro Byun; Kwangmeyung Kim; Ick Chan Kwon; Sang Yoon Kim; Soon Hong Yuk

doi:10.1016/j.biomaterials.2013.07.040

Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Jae Yeon Kim
, Hwanbum Lee
, Keun Sang Oh
, Seho Kweon
, Ok cheol Jeon
, Youngro Byun
, Kwangmeyung Kim
, Ick Chan Kwon
, Sang Yoon Kim
, Soon Hong Yuk^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

Original language	English
Pages (from-to)	8444-8449
Number of pages	6
Journal	Biomaterials
Volume	34
Issue number	33
DOIs	https://doi.org/10.1016/j.biomaterials.2013.07.040
Publication status	Published - 2013 Nov

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Core/shell nanoparticles
Layer-by-layer approach
Lipid bilayers
Pluronics
Sustained delivery of exenatide

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2013.07.040

Cite this

@article{13766cc07402483fb3b8dbd86764a8d3,

title = "Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus",

abstract = "A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.",

keywords = "Core/shell nanoparticles, Layer-by-layer approach, Lipid bilayers, Pluronics, Sustained delivery of exenatide",

author = "Kim, \{Jae Yeon\} and Hwanbum Lee and Oh, \{Keun Sang\} and Seho Kweon and Jeon, \{Ok cheol\} and Youngro Byun and Kwangmeyung Kim and Kwon, \{Ick Chan\} and Kim, \{Sang Yoon\} and Yuk, \{Soon Hong\}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).",

year = "2013",

month = nov,

doi = "10.1016/j.biomaterials.2013.07.040",

language = "English",

volume = "34",

pages = "8444--8449",

journal = "Biomaterials",

issn = "0142-9612",

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T1 - Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

AU - Kim, Jae Yeon

AU - Lee, Hwanbum

AU - Oh, Keun Sang

AU - Kweon, Seho

AU - Jeon, Ok cheol

AU - Byun, Youngro

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

AU - Kim, Sang Yoon

AU - Yuk, Soon Hong

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korean government (MEST) ( 20110027932 and 2012028831 ).

PY - 2013/11

Y1 - 2013/11

N2 - A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

AB - A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The invitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using invivo animal models. Invitro-. invivo correlation was discussed in relation to manipulation of the NP structures.

KW - Core/shell nanoparticles

KW - Layer-by-layer approach

KW - Lipid bilayers

KW - Pluronics

KW - Sustained delivery of exenatide

UR - https://www.scopus.com/pages/publications/84881663280

U2 - 10.1016/j.biomaterials.2013.07.040

DO - 10.1016/j.biomaterials.2013.07.040

M3 - Article

C2 - 23895999

AN - SCOPUS:84881663280

SN - 0142-9612

VL - 34

SP - 8444

EP - 8449

JO - Biomaterials

JF - Biomaterials

IS - 33

ER -

Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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