Multimodal hyper-connectivity networks for MCI classification

Yang Li, Xinqiang Gao, Biao Jie, Pew Thian Yap, Min jeong Kim, Chong Yaw Wee, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)


Hyper-connectivity network is a network where every edge is connected to more than two nodes, and can be naturally denoted using a hyper-graph. Hyper-connectivity brain network, either based on structural or functional interactions among the brain regions, has been used for brain disease diagnosis. However, the conventional hyper-connectivity network is constructed solely based on single modality data, ignoring potential complementary information conveyed by other modalities. The integration of complementary information from multiple modalities has been shown to provide a more comprehensive representation about the brain disruptions. In this paper, a novel multimodal hyper-network modelling method was proposed for improving the diagnostic accuracy of mild cognitive impairment (MCI). Specifically, we first constructed a multimodal hyper-connectivity network by simultaneously considering information from diffusion tensor imaging and resting-state functional magnetic resonance imaging data. We then extracted different types of network features from the hyper-connectivity network, and further exploited a manifold regularized multi-task feature selection method to jointly select the most discriminative features. Our proposed multimodal hyper-connectivity network demonstrated a better MCI classification performance than the conventional single modality based hyper-connectivity networks.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings
EditorsMaxime Descoteaux, Simon Duchesne, Alfred Franz, Pierre Jannin, D. Louis Collins, Lena Maier-Hein
PublisherSpringer Verlag
Number of pages9
ISBN (Print)9783319661810
Publication statusPublished - 2017
Event20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017 - Quebec City, Canada
Duration: 2017 Sept 112017 Sept 13

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10433 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other20th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2017
CityQuebec City

Bibliographical note

Publisher Copyright:
© 2017, Springer International Publishing AG.

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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