Multimodal label-free detection and discrimination for small molecules using a nanoporous resonator

Jinsung Park, Doyeon Bang, Kuewhan Jang, Eunkyoung Kim, Seungjoo Haam, Sungsoo Na

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


To detect chemical or biological threats, it is crucial that sensor devices can differentiate various target molecules. In general, each different sensing method has its own strengths and weaknesses due to their respective limitations. For example, although resonant sensors have high sensitivity, they are not able to discriminate target molecules. At the same time, although surface-enhanced Raman spectroscopy is a representative label-free detection method that can discriminate target molecules, its fabrication is often complex and expensive. Here we present a label-free multimodal nanoporous resonator-based system for small molecule detection and discrimination that combines the strengths of each of these sensing methods. Our approach is not only able to improve the sensitivity of the resonant sensor but it can also discriminate the target molecules. Furthermore, the fabrication process is swift (lasting <3ǎ €‰min) and convenient.

Original languageEnglish
Article number3456
JournalNature communications
Publication statusPublished - 2014 Mar 28

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) under grant nos NRF-2013-044213, ERC-2007-0056094 and NRF-2013058102, which is funded by the Ministry of Science, ICT & Future Planning. Further, this work was supported by BioNano Health-Guard Research Center funded by the Ministry of Science, ICT & Future Planning (MSIP) of Korea as Global Frontier Project (grant no. H-GUARD_2013M3A6B2078946).

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General
  • General Physics and Astronomy


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