Multiphoton microscopy: An introduction to gastroenterologists

Hye Jin Cho, Hoon Jai Chun, Eun Sun Kim, Bong Rae Cho

Research output: Contribution to journalEditorialpeer-review

14 Citations (Scopus)


Multiphoton microscopy, relying on the simultaneous absorption of two or more photons by a fuorophore, has come to occupy a prominent place in modern biomedical research with its ability to allow real-time observation of a single cell and molecules in intact tissues. Multiphoton microscopy exhibits nonlinear optical contrast properties, which can make it possible to provide an exceptionally large depth penetration with less phototoxicity. This system becomes more and more an inspiring tool for a non-invasive imaging system to realize "optical biopsy" and to examine the functions of living cells. In this review, we briefly present the physical principles and properties of multiphoton microscopy as well as the current applications in biological fields. In addition, we address what we see as the future potential of multiphoton microscopy for gastroenterologic research.

Original languageEnglish
Pages (from-to)4456-4460
Number of pages5
JournalWorld journal of gastroenterology
Issue number40
Publication statusPublished - 2011
Externally publishedYes


  • Gastrointestinal disease
  • Multiphoton microscopy
  • Optical biopsy

ASJC Scopus subject areas

  • Gastroenterology


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