TY - JOUR
T1 - Multiple predictors of coronary restenosis after drug-eluting stent implantation in patients with diabetes
AU - Hong, S. J.
AU - Kim, M. H.
AU - Ahn, T. H.
AU - Ahn, Y. K.
AU - Bae, J. H.
AU - Shim, W. J.
AU - Ro, Y. M.
AU - Lim, Do Sun
PY - 2006/8
Y1 - 2006/8
N2 - Objectives: To identify parameters influencing the likelihood of restenosis after implantation of drug-eluting stents (DES) in patients with diabetes. Methods: Stented patients (n = 840) with DES were retrospectively reviewed for inclusion in the study from the Multicenter PCI Database Registry. From this database, 211 (25.1%) of 840 patients with six-month angiographic follow up had diabetes. Predictors of coronary restenosis were identified with univariate and multivariate logistic regression analyses. Results: Restenosis occurred in 92 of 629 (14.6%) patients without diabetes and in 44 (20.9%) of 211 patients with diabetes (p < 0.001). Multivariate parameters for predicting restenosis in the diabetic group were current smoking (odds ratio (OR) 1.923, 95% confidence interval (Cl) 1.055 to 4.725, p = 0.036), higher C reactive protein concentration (OR 1.031, 95% Cl 1.011 to 1.075, p = 0.043), use of the paclitaxel-eluting stent (OR 2.638, 95% Cl 1.338 to 5.200, p = 0.005), longer stent length (OR 1.065, 95% Cl 1.021 to 1.119, p = 0.033), smaller reference diameter before DES implantation (OR 0.501, 95% Cl 0.110 to 0.965, p = 0.040), smaller reference diameter (OR 0.455, 95% Cl 0.120 to 0.814, p = 0.026) and minimum lumen diameter (OR 0.447, 95% Cl 0.068 to 0.876, p = 0.039) after DES implantation. Conclusion: Even with the introduction of DES, diabetes remains a significant predictor of coronary restenosis, especially in cases of a small baseline vessel size, small vessel size after percutaneous coronary intervention, longer stent length, use of the paclitaxel-eluting stent, current smoking and high C reactive protein concentration.
AB - Objectives: To identify parameters influencing the likelihood of restenosis after implantation of drug-eluting stents (DES) in patients with diabetes. Methods: Stented patients (n = 840) with DES were retrospectively reviewed for inclusion in the study from the Multicenter PCI Database Registry. From this database, 211 (25.1%) of 840 patients with six-month angiographic follow up had diabetes. Predictors of coronary restenosis were identified with univariate and multivariate logistic regression analyses. Results: Restenosis occurred in 92 of 629 (14.6%) patients without diabetes and in 44 (20.9%) of 211 patients with diabetes (p < 0.001). Multivariate parameters for predicting restenosis in the diabetic group were current smoking (odds ratio (OR) 1.923, 95% confidence interval (Cl) 1.055 to 4.725, p = 0.036), higher C reactive protein concentration (OR 1.031, 95% Cl 1.011 to 1.075, p = 0.043), use of the paclitaxel-eluting stent (OR 2.638, 95% Cl 1.338 to 5.200, p = 0.005), longer stent length (OR 1.065, 95% Cl 1.021 to 1.119, p = 0.033), smaller reference diameter before DES implantation (OR 0.501, 95% Cl 0.110 to 0.965, p = 0.040), smaller reference diameter (OR 0.455, 95% Cl 0.120 to 0.814, p = 0.026) and minimum lumen diameter (OR 0.447, 95% Cl 0.068 to 0.876, p = 0.039) after DES implantation. Conclusion: Even with the introduction of DES, diabetes remains a significant predictor of coronary restenosis, especially in cases of a small baseline vessel size, small vessel size after percutaneous coronary intervention, longer stent length, use of the paclitaxel-eluting stent, current smoking and high C reactive protein concentration.
UR - http://www.scopus.com/inward/record.url?scp=33746428356&partnerID=8YFLogxK
U2 - 10.1136/hrt.2005.075960
DO - 10.1136/hrt.2005.075960
M3 - Article
C2 - 16449516
AN - SCOPUS:33746428356
SN - 1355-6037
VL - 92
SP - 1119
EP - 1124
JO - Heart
JF - Heart
IS - 8
ER -