Abstract
Turn off the lights! A universal nanoquencher that quenches a broad range of visible to near-infrared dyes by using a series of dark quenchers incorporated into a cell-permeable mesoporous silica nanoparticle has been developed. In combination with dye-labeled substrates, this nanoquencher boosts multiple fluorescence signals upon specific proteolysis, which allows real-time imaging of proteolytic cascades (see scheme).
Original language | English |
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Pages (from-to) | 1625-1630 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2012 Feb 13 |
Externally published | Yes |
Keywords
- caspases
- fluorescence
- imaging agents
- nanoparticles
- proteolysis
ASJC Scopus subject areas
- Catalysis
- General Chemistry