Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes

Savka I. Stoeva; Jae Seung Lee; Jennifer E. Smith; Steven T. Rosen; Chad A. Mirkin

doi:10.1021/ja0613106

Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes

Savka I. Stoeva, Jae Seung Lee, Jennifer E. Smith, Steven T. Rosen, Chad A. Mirkin

Research output: Contribution to journal › Article › peer-review

387 Citations (Scopus)

Abstract

We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings.

Original language	English
Pages (from-to)	8378-8379
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	26
DOIs	https://doi.org/10.1021/ja0613106
Publication status	Published - 2006 Jul 5
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja0613106

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AU - Rosen, Steven T.

AU - Mirkin, Chad A.

PY - 2006/7/5

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AB - We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings.

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Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes

Abstract

ASJC Scopus subject areas

UN SDGs

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