Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes

Savka I. Stoeva, Jae Seung Lee, Jennifer E. Smith, Steven T. Rosen, Chad A. Mirkin

Research output: Contribution to journalArticlepeer-review

400 Citations (Scopus)


We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings.

Original languageEnglish
Pages (from-to)8378-8379
Number of pages2
JournalJournal of the American Chemical Society
Issue number26
Publication statusPublished - 2006 Jul 5
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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