Multiview Feature Learning With Multiatlas-Based Functional Connectivity Networks for MCI Diagnosis

Yu Zhang, Han Zhang, Ehsan Adeli, Xiaobo Chen, Mingxia Liu, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Functional connectivity (FC) networks built from resting-state functional magnetic resonance imaging (rs-fMRI) has shown promising results for the diagnosis of Alzheimer's disease and its prodromal stage, that is, mild cognitive impairment (MCI). FC is usually estimated as a temporal correlation of regional mean rs-fMRI signals between any pair of brain regions, and these regions are traditionally parcellated with a particular brain atlas. Most existing studies have adopted a predefined brain atlas for all subjects. However, the constructed FC networks inevitably ignore the potentially important subject-specific information, particularly, the subject-specific brain parcellation. Similar to the drawback of the 'single view' (versus the 'multiview' learning) in medical image-based classification, FC networks constructed based on a single atlas may not be sufficient to reveal the underlying complicated differences between normal controls and disease-affected patients due to the potential bias from that particular atlas. In this study, we propose a multiview feature learning method with multiatlas-based FC networks to improve MCI diagnosis. Specifically, a three-step transformation is implemented to generate multiple individually specified atlases from the standard automated anatomical labeling template, from which a set of atlas exemplars is selected. Multiple FC networks are constructed based on these preselected atlas exemplars, providing multiple views of the FC network-based feature representations for each subject. We then devise a multitask learning algorithm for joint feature selection from the constructed multiple FC networks. The selected features are jointly fed into a support vector machine classifier for multiatlas-based MCI diagnosis. Extensive experimental comparisons are carried out between the proposed method and other competing approaches, including the traditional single-atlas-based method. The results indicate that our method significantly improves the MCI classification, demonstrating its promise in the brain connectome-based individualized diagnosis of brain diseases.

Original languageEnglish
Pages (from-to)6822-6833
Number of pages12
JournalIEEE Transactions on Cybernetics
Issue number7
Publication statusPublished - 2022 Jul 1

Bibliographical note

Publisher Copyright:
© 2013 IEEE.


  • Brain disease diagnosis
  • functional connectivity (FC)
  • mild cognitive impairment (MCI)
  • multinetwork classification
  • resting-state functional magnetic resonance imaging (rs-fMRI)

ASJC Scopus subject areas

  • Software
  • Control and Systems Engineering
  • Information Systems
  • Human-Computer Interaction
  • Computer Science Applications
  • Electrical and Electronic Engineering


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