Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

M. H. Kang; K. J. Jeong; W. Y. Kim; H. J. Lee; G. Gong; N. Suh; B. Gyrffy; S. Kim; S. Y. Jeong; G. B. Mills; Y. Y. Park

doi:10.1038/onc.2016.327

Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

M. H. Kang, K. J. Jeong, W. Y. Kim, H. J. Lee, G. Gong, N. Suh, B. Gyrffy, S. Kim, S. Y. Jeong, G. B. Mills, Y. Y. Park

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Based on gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream target genes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

Original language	English
Pages (from-to)	1745-1752
Number of pages	8
Journal	Oncogene
Volume	36
Issue number	12
DOIs	https://doi.org/10.1038/onc.2016.327
Publication status	Published - 2017 Mar 23
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the Ministry of Education (NRF-2014R1A1A2053529 to Y-YP; NRF-2013R1A1A2064367 to M-HK) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HI15C0972 to Y-YP).

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/onc.2016.327

Cite this

@article{fcf02e9bdebc43fc9ea783defc29263d,

title = "Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer",

abstract = "Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Based on gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream target genes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.",

author = "Kang, {M. H.} and Jeong, {K. J.} and Kim, {W. Y.} and Lee, {H. J.} and G. Gong and N. Suh and B. Gyrffy and S. Kim and Jeong, {S. Y.} and Mills, {G. B.} and Park, {Y. Y.}",

note = "Funding Information: This research was supported by the Ministry of Education (NRF-2014R1A1A2053529 to Y-YP; NRF-2013R1A1A2064367 to M-HK) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HI15C0972 to Y-YP).",

year = "2017",

month = mar,

day = "23",

doi = "10.1038/onc.2016.327",

language = "English",

volume = "36",

pages = "1745--1752",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Springer Nature",

number = "12",

}

TY - JOUR

T1 - Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

AU - Kang, M. H.

AU - Jeong, K. J.

AU - Kim, W. Y.

AU - Lee, H. J.

AU - Gong, G.

AU - Suh, N.

AU - Gyrffy, B.

AU - Kim, S.

AU - Jeong, S. Y.

AU - Mills, G. B.

AU - Park, Y. Y.

N1 - Funding Information: This research was supported by the Ministry of Education (NRF-2014R1A1A2053529 to Y-YP; NRF-2013R1A1A2064367 to M-HK) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (HI15C0972 to Y-YP).

PY - 2017/3/23

Y1 - 2017/3/23

N2 - Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Based on gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream target genes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

AB - Musashi RNA-binding protein 2 (MSI2) has important roles in human cancer. However, the regulatory mechanisms by which MSI2 alters breast cancer pathophysiology have not been clearly identified. Here we demonstrate that MSI2 directly regulates estrogen receptor 1 (ESR1), which is a well-known therapeutic target and has been shown to reflect clinical outcomes in breast cancer. Based on gene expression data analysis, we found that MSI2 expression was highly enriched in estrogen receptor (ER)-positive breast cancer and that MSI2 expression was significantly correlated with ESR1 expression, including expression of ESR1 downstream target genes. In addition, MSI2 levels were associated with clinical outcomes. MSI2 influenced breast cancer cell growth by altering ESR1 function. MSI2 alters ESR1 by binding specific sites in ESR1 RNA and by increasing ESR1 protein stability. Taken together, our findings identified a novel regulatory mechanism of MSI2 as an upstream regulator of ESR1 and revealed the clinical relevance of the RNA-binding protein MSI2 in breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=84991034747&partnerID=8YFLogxK

U2 - 10.1038/onc.2016.327

DO - 10.1038/onc.2016.327

M3 - Article

C2 - 27593929

AN - SCOPUS:84991034747

SN - 0950-9232

VL - 36

SP - 1745

EP - 1752

JO - Oncogene

JF - Oncogene

IS - 12

ER -

Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this