Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Hyo Jeong Kim; Byeong Hee Hwang; Seonghye Lim; Bong Hyuk Choi; Seok Ho Kang; Hyung Joon Cha

doi:10.1016/j.biomaterials.2015.08.055

Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Hyo Jeong Kim, Byeong Hee Hwang, Seonghye Lim, Bong Hyuk Choi, Seok Ho Kang, Hyung Joon Cha

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

Original language	English
Pages (from-to)	104-111
Number of pages	8
Journal	Biomaterials
Volume	72
DOIs	https://doi.org/10.1016/j.biomaterials.2015.08.055
Publication status	Published - 2015 Dec
Externally published	Yes

Bibliographical note

Funding Information:
Financial support was provided by the Marine Biotechnology program ( Marine BioMaterials Research Center ) funded by the Ministry of Oceans and Fisheries ( D11013214H480000110 ), Korea.

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Complex coacervation
DOPA
Mussel adhesive proteins
Underwater adhesion
Urinary fistula

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2015.08.055

Cite this

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title = "Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing",

abstract = "Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.",

keywords = "Complex coacervation, DOPA, Mussel adhesive proteins, Underwater adhesion, Urinary fistula",

author = "Kim, {Hyo Jeong} and Hwang, {Byeong Hee} and Seonghye Lim and Choi, {Bong Hyuk} and Kang, {Seok Ho} and Cha, {Hyung Joon}",

note = "Funding Information: Financial support was provided by the Marine Biotechnology program ( Marine BioMaterials Research Center ) funded by the Ministry of Oceans and Fisheries ( D11013214H480000110 ), Korea. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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AU - Kim, Hyo Jeong

AU - Hwang, Byeong Hee

AU - Lim, Seonghye

AU - Choi, Bong Hyuk

AU - Kang, Seok Ho

AU - Cha, Hyung Joon

N1 - Funding Information: Financial support was provided by the Marine Biotechnology program ( Marine BioMaterials Research Center ) funded by the Ministry of Oceans and Fisheries ( D11013214H480000110 ), Korea. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/12

Y1 - 2015/12

N2 - Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

AB - Urinary fistulas, abnormal openings of a urinary tract organ, are serious complications and conventional management strategies are not satisfactory. For more effective and non-invasive fistula repair, fluid tissue adhesives or sealants have been suggested. However, conventional products do not provide a suitable solution due to safety problems and poor underwater adhesion under physiological conditions. Herein, we proposed a unique water-immiscible mussel protein-based bioadhesive (WIMBA) exhibiting strong underwater adhesion which was employed by two adhesion strategies of marine organisms; 3,4-dihydroxy- l-phenylalanine (DOPA)-mediated strong adhesion and water-immiscible coacervation. The developed biocompatible WIMBA successfully sealed ex vivo urinary fistulas and provided good durability and high compliance. Thus, WIMBA could be used as a promising sealant for urinary fistula management with further expansion to diverse internal body applications.

KW - Complex coacervation

KW - DOPA

KW - Mussel adhesive proteins

KW - Underwater adhesion

KW - Urinary fistula

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Mussel adhesion-employed water-immiscible fluid bioadhesive for urinary fistula sealing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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