Mutations in the human 5-lipoxygenase gene

Kwang Ho In, Eric S. Silverman, Koichiro Asano, David Beier, Andrew R. Fischer, Tim P. Keith, Kristina Serino, Chandri Yandava, George T. De Sanctis, Jeffrey M. Drazen

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the variant alleles can bind Sp1 and Egr-1 protein, as indicated by EMSA and supershift analysis with nuclear extracts. In addition, preliminary data from CAT reporter assays indicate that these alleles are less effective than the wild-type allele in initiating 5-LO gene expression. Whether patients harboring the various alleles identified herein have different capacities to transcribe the 5-LO gene and the importance of such potential regulation to the clinical expression of 5-LO have yet to be determined.

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalClinical Reviews in Allergy and Immunology
Issue number1-2
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy


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