Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

Seung Jun Lee; Jong Hwa Jang; Gun Young Yoon; Da Rae Kang; Hee Jo Park; Sung Jae Shin; Hee Dong Han; Tae Heung Kang; Won Sun Park; Young Kyung Yoon; Byoung Yul Soh; In Duk Jung; Yeong Min Park

doi:10.5483/BMBRep.2016.49.10.080

Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

Seung Jun Lee, Jong Hwa Jang, Gun Young Yoon, Da Rae Kang, Hee Jo Park, Sung Jae Shin, Hee Dong Han, Tae Heung Kang, Won Sun Park, Young Kyung Yoon, Byoung Yul Soh, In Duk Jung, Yeong Min Park

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

Original language	English
Pages (from-to)	554-559
Number of pages	6
Journal	BMB reports
Volume	49
Issue number	10
DOIs	https://doi.org/10.5483/BMBRep.2016.49.10.080
Publication status	Published - 2016
Externally published	Yes

Keywords

Dendritic cells
MAB1843
MAPK
Mycobacterium abscessus
Th1 polarization

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5483/BMBRep.2016.49.10.080

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Lee, S. J., Jang, J. H., Yoon, G. Y., Kang, D. R., Park, H. J., Shin, S. J., Han, H. D., Kang, T. H., Park, W. S., Yoon, Y. K., Soh, B. Y., Jung, I. D., & Park, Y. M. (2016). Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity. BMB reports, 49(10), 554-559. https://doi.org/10.5483/BMBRep.2016.49.10.080

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title = "Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity",

abstract = "Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.",

keywords = "Dendritic cells, MAB1843, MAPK, Mycobacterium abscessus, Th1 polarization",

author = "Lee, {Seung Jun} and Jang, {Jong Hwa} and Yoon, {Gun Young} and Kang, {Da Rae} and Park, {Hee Jo} and Shin, {Sung Jae} and Han, {Hee Dong} and Kang, {Tae Heung} and Park, {Won Sun} and Yoon, {Young Kyung} and Soh, {Byoung Yul} and Jung, {In Duk} and Park, {Yeong Min}",

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doi = "10.5483/BMBRep.2016.49.10.080",

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T1 - Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

AU - Lee, Seung Jun

AU - Jang, Jong Hwa

AU - Yoon, Gun Young

AU - Kang, Da Rae

AU - Park, Hee Jo

AU - Shin, Sung Jae

AU - Han, Hee Dong

AU - Kang, Tae Heung

AU - Park, Won Sun

AU - Yoon, Young Kyung

AU - Soh, Byoung Yul

AU - Jung, In Duk

AU - Park, Yeong Min

PY - 2016

Y1 - 2016

N2 - Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

AB - Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.

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Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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