N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Jong Kuk Park; Young Min Chung; Byung Gyu Kim; Young A. Yoo; Beom Seok Yang; Jun Suk Kim; Young Do Yoo

N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Jong Kuk Park
, Young Min Chung
, Byung Gyu Kim
, Young A. Yoo
, Beom Seok Yang
, Jun Suk Kim
, Young Do Yoo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.

Original language	English
Pages (from-to)	403-407
Number of pages	5
Journal	Molecular cancer therapeutics
Volume	3
Issue number	4
Publication status	Published - 2004 Apr

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells",

abstract = "To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.",

author = "Park, \{Jong Kuk\} and Chung, \{Young Min\} and Kim, \{Byung Gyu\} and Yoo, \{Young A.\} and Yang, \{Beom Seok\} and Kim, \{Jun Suk\} and Yoo, \{Young Do\}",

year = "2004",

month = apr,

language = "English",

volume = "3",

pages = "403--407",

journal = "Molecular cancer therapeutics",

issn = "1535-7163",

publisher = "American Association for Cancer Research Inc.",

number = "4",

}

TY - JOUR

T1 - N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

AU - Park, Jong Kuk

AU - Chung, Young Min

AU - Kim, Byung Gyu

AU - Yoo, Young A.

AU - Yang, Beom Seok

AU - Kim, Jun Suk

AU - Yoo, Young Do

PY - 2004/4

Y1 - 2004/4

N2 - To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.

AB - To develop a new radiosensitizer, we screened a chemical library and selected one chemical reagent, N′-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester (PHCM), which was already known to have antifungal and antimicrobial properties. PHCM enhanced radiation-induced cell death and its mean calculated dose enhancement ratio was 1.17. PHCM was found to induce the phosphorylation of p38 mitogen-activated protein kinase, and combined treatment with PHCM and radiation down-regulated Bcl-2. In a xenograft assay, the combined PHCM and radiation group showed 39.3 days of growth delay versus the control in terms of tumor growth. The enhancement factor of this combined treatment was determined to be 4.02.

UR - https://www.scopus.com/pages/publications/4444334493

M3 - Article

C2 - 15078983

AN - SCOPUS:4444334493

SN - 1535-7163

VL - 3

SP - 403

EP - 407

JO - Molecular cancer therapeutics

JF - Molecular cancer therapeutics

IS - 4

ER -

N′-(phenyl-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells

Abstract

ASJC Scopus subject areas

UN SDGs

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