NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Hye Eun Lee; Seunghwan Shim; Yongseok Choi; Yun Soo Bae

doi:10.23876/j.krcp.21.269

NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Hye Eun Lee, Seunghwan Shim, Yongseok Choi, Yun Soo Bae

Department of Biotechnology

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.

Original language	English
Pages (from-to)	S89-S98
Journal	Kidney Research and Clinical Practice
Volume	41
DOIs	https://doi.org/10.23876/j.krcp.21.269
Publication status	Published - 2022 Sept 1

Keywords

Diabetic nephropathies
NADPH oxidases
Nox inhibitor
Oxidative stress
Reactive oxygen species

ASJC Scopus subject areas

Nephrology
Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.23876/j.krcp.21.269

Cite this

@article{8161b3245f5541a5a7ad038e0833c83a,

title = "NADPH oxidase inhibitor development for diabetic nephropathy through water tank model",

abstract = "Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.",

keywords = "Diabetic nephropathies, NADPH oxidases, Nox inhibitor, Oxidative stress, Reactive oxygen species",

author = "Lee, {Hye Eun} and Seunghwan Shim and Yongseok Choi and Bae, {Yun Soo}",

note = "Funding Information: A9D8062955 to YSB) and Bio-SPC (2018M3A9G1075771 to YSB) funded by the National Research Foundation of Korea (NRF) and Ministry of Science and ICT, and by a grant from the Korea Health Technology R&D Project (HI21C0293 to HEL) through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare. Publisher Copyright: {\textcopyright} 2022 by The Korean Society of Nephrology.",

year = "2022",

month = sep,

day = "1",

doi = "10.23876/j.krcp.21.269",

language = "English",

volume = "41",

pages = "S89--S98",

journal = "Kidney Research and Clinical Practice",

issn = "2211-9132",

publisher = "Elsevier Korea",

}

TY - JOUR

T1 - NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

AU - Lee, Hye Eun

AU - Shim, Seunghwan

AU - Choi, Yongseok

AU - Bae, Yun Soo

N1 - Funding Information: A9D8062955 to YSB) and Bio-SPC (2018M3A9G1075771 to YSB) funded by the National Research Foundation of Korea (NRF) and Ministry of Science and ICT, and by a grant from the Korea Health Technology R&D Project (HI21C0293 to HEL) through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare. Publisher Copyright: © 2022 by The Korean Society of Nephrology.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.

AB - Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.

KW - Diabetic nephropathies

KW - NADPH oxidases

KW - Nox inhibitor

KW - Oxidative stress

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=85139471498&partnerID=8YFLogxK

U2 - 10.23876/j.krcp.21.269

DO - 10.23876/j.krcp.21.269

M3 - Review article

AN - SCOPUS:85139471498

SN - 2211-9132

VL - 41

SP - S89-S98

JO - Kidney Research and Clinical Practice

JF - Kidney Research and Clinical Practice

ER -

NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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