Nafion-stabilized two-dimensional transition metal carbide (Ti3C2Tx MXene) as a high-performance electrochemical sensor for neurotransmitter

Faisal Shahzad; Aamir Iqbal; Shabi Abbas Zaidi; Suk Won Hwang; Chong Min Koo

doi:10.1016/j.jiec.2019.03.061

Nafion-stabilized two-dimensional transition metal carbide (Ti₃C₂T_x MXene) as a high-performance electrochemical sensor for neurotransmitter

Faisal Shahzad, Aamir Iqbal, Shabi Abbas Zaidi, Suk Won Hwang, Chong Min Koo

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Herein, we demonstrate the selective sensing of Dopamine (DA), an important neurotransmitter, by using Nafion-stabilized two-dimensional transition metal carbides (Ti₃C₂T_x MXenes). Ti₃C₂T_x was deposited on a glassy carbon electrode followed by Nafion coating to achieve a robust sensitivity (∼3 nM), good selectivity, wide detection window (0.015–10 μM), high stability, reproducibility, and outstanding recoveries for DA detection in real samples. MXene-based biosensor exhibited much better electrochemical performance when compared with reduced graphene oxide-based biosensor under similar experimental conditions due to the MXenes good electrical conductivity and negatively charged surface which assisted in the selective and sensitive detection of DA.

Original language	English
Pages (from-to)	338-344
Number of pages	7
Journal	Journal of Industrial and Engineering Chemistry
Volume	79
DOIs	https://doi.org/10.1016/j.jiec.2019.03.061
Publication status	Published - 2019 Nov 25

Keywords

Dopamine
Electrochemical sensor
MXenes
TiC
Two-dimensional transition metal carbides

ASJC Scopus subject areas

Chemical Engineering(all)

Access to Document

10.1016/j.jiec.2019.03.061

Cite this

@article{15c3a874f8b6448b8a0627ba37cc8ead,

title = "Nafion-stabilized two-dimensional transition metal carbide (Ti3C2Tx MXene) as a high-performance electrochemical sensor for neurotransmitter",

abstract = "Herein, we demonstrate the selective sensing of Dopamine (DA), an important neurotransmitter, by using Nafion-stabilized two-dimensional transition metal carbides (Ti3C2Tx MXenes). Ti3C2Tx was deposited on a glassy carbon electrode followed by Nafion coating to achieve a robust sensitivity (∼3 nM), good selectivity, wide detection window (0.015–10 μM), high stability, reproducibility, and outstanding recoveries for DA detection in real samples. MXene-based biosensor exhibited much better electrochemical performance when compared with reduced graphene oxide-based biosensor under similar experimental conditions due to the MXenes good electrical conductivity and negatively charged surface which assisted in the selective and sensitive detection of DA.",

keywords = "Dopamine, Electrochemical sensor, MXenes, TiC, Two-dimensional transition metal carbides",

author = "Faisal Shahzad and Aamir Iqbal and Zaidi, {Shabi Abbas} and Hwang, {Suk Won} and Koo, {Chong Min}",

note = "Funding Information: This work was financially supported by a grant from the Basic Science Research Program ( 2017R1A2B3006469 ) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning , the Fundamental R&D Program ( 10077545 ) for the Core Technology of Materials, and the Industrial Strategic Technology Development Program funded by the Ministry of Knowledge Economy , Smart Civil Infrastructure Research Program (SCIP) ( 18SCIP-B146646-01 ) funded by Ministry of Land, Infrastructure and Transport , Republic of Korea. Partial funding was provided by the Materials Architecturing Research Center, Young Fellow, KU-KIST School Program of the Korea Institute of Science and Technology (KIST) and Korea University . SAZ is grateful for partial funding from Qatar University, Qatar. FS acknowledges the financial support from Higher Education Commission ( HEC ) of Pakistan and from KIST School Partnership Project (RFP-2019), Republic of Korea. Publisher Copyright: {\textcopyright} 2019 The Korean Society of Industrial and Engineering Chemistry",

year = "2019",

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doi = "10.1016/j.jiec.2019.03.061",

language = "English",

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AU - Shahzad, Faisal

AU - Iqbal, Aamir

AU - Zaidi, Shabi Abbas

AU - Hwang, Suk Won

AU - Koo, Chong Min

N1 - Funding Information: This work was financially supported by a grant from the Basic Science Research Program ( 2017R1A2B3006469 ) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning , the Fundamental R&D Program ( 10077545 ) for the Core Technology of Materials, and the Industrial Strategic Technology Development Program funded by the Ministry of Knowledge Economy , Smart Civil Infrastructure Research Program (SCIP) ( 18SCIP-B146646-01 ) funded by Ministry of Land, Infrastructure and Transport , Republic of Korea. Partial funding was provided by the Materials Architecturing Research Center, Young Fellow, KU-KIST School Program of the Korea Institute of Science and Technology (KIST) and Korea University . SAZ is grateful for partial funding from Qatar University, Qatar. FS acknowledges the financial support from Higher Education Commission ( HEC ) of Pakistan and from KIST School Partnership Project (RFP-2019), Republic of Korea. Publisher Copyright: © 2019 The Korean Society of Industrial and Engineering Chemistry

PY - 2019/11/25

Y1 - 2019/11/25

N2 - Herein, we demonstrate the selective sensing of Dopamine (DA), an important neurotransmitter, by using Nafion-stabilized two-dimensional transition metal carbides (Ti3C2Tx MXenes). Ti3C2Tx was deposited on a glassy carbon electrode followed by Nafion coating to achieve a robust sensitivity (∼3 nM), good selectivity, wide detection window (0.015–10 μM), high stability, reproducibility, and outstanding recoveries for DA detection in real samples. MXene-based biosensor exhibited much better electrochemical performance when compared with reduced graphene oxide-based biosensor under similar experimental conditions due to the MXenes good electrical conductivity and negatively charged surface which assisted in the selective and sensitive detection of DA.

AB - Herein, we demonstrate the selective sensing of Dopamine (DA), an important neurotransmitter, by using Nafion-stabilized two-dimensional transition metal carbides (Ti3C2Tx MXenes). Ti3C2Tx was deposited on a glassy carbon electrode followed by Nafion coating to achieve a robust sensitivity (∼3 nM), good selectivity, wide detection window (0.015–10 μM), high stability, reproducibility, and outstanding recoveries for DA detection in real samples. MXene-based biosensor exhibited much better electrochemical performance when compared with reduced graphene oxide-based biosensor under similar experimental conditions due to the MXenes good electrical conductivity and negatively charged surface which assisted in the selective and sensitive detection of DA.

KW - Dopamine

KW - Electrochemical sensor

KW - MXenes

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