Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim; Junghyo Yoon; Jae Yeong Byun; Hyunho Kim; Sewoon Han; Junghyun Kim; Jeong Hoon Lee; Han Sang Jo; Seok Chung

doi:10.3390/s21041366

Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim, Junghyo Yoon, Jae Yeong Byun, Hyunho Kim, Sewoon Han, Junghyun Kim, Jeong Hoon Lee, Han Sang Jo, Seok Chung

School of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

Original language	English
Article number	1366
Pages (from-to)	1-19
Number of pages	19
Journal	Sensors (Switzerland)
Volume	21
Issue number	4
DOIs	https://doi.org/10.3390/s21041366
Publication status	Published - 2021 Feb 2

Bibliographical note

Funding Information:
Author Contributions: Conceptualization, J.-Y.B. and S.H.; methodology, H.-S.J.; software, J.K.; validation, H.K., J.K. and J.Y.; formal analysis, J.-Y.B.; writing—original draft preparation, J.K. and J.Y.; writing—review and editing, H.K. and S. C.; visualization, H.-S.J.; supervision, J.H.L. and S.C.; funding acquisition, S.C. All authors have read and agreed to the published version of the manuscript Funding: This work was supported by Samsung Research Funding & Incubation Center of Samsung Electronics under Project Number SRFC-MA1502-51.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Blood plasma extraction
Microfluidics
Point-of-care testing

ASJC Scopus subject areas

Analytical Chemistry
Information Systems
Instrumentation
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering
Biochemistry

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10.3390/s21041366

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title = "Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device",

abstract = "Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.",

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AU - Jo, Han Sang

AU - Chung, Seok

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N2 - Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

AB - Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

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Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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