Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim, Junghyo Yoon, Jae Yeong Byun, Hyunho Kim, Sewoon Han, Junghyun Kim, Jeong Hoon Lee, Han Sang Jo, Seok Chung

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

Original languageEnglish
Article number1366
Pages (from-to)1-19
Number of pages19
JournalSensors (Switzerland)
Issue number4
Publication statusPublished - 2021 Feb 2

Bibliographical note

Funding Information:
Author Contributions: Conceptualization, J.-Y.B. and S.H.; methodology, H.-S.J.; software, J.K.; validation, H.K., J.K. and J.Y.; formal analysis, J.-Y.B.; writing—original draft preparation, J.K. and J.Y.; writing—review and editing, H.K. and S. C.; visualization, H.-S.J.; supervision, J.H.L. and S.C.; funding acquisition, S.C. All authors have read and agreed to the published version of the manuscript Funding: This work was supported by Samsung Research Funding & Incubation Center of Samsung Electronics under Project Number SRFC-MA1502-51.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Blood plasma extraction
  • Microfluidics
  • Point-of-care testing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Instrumentation
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering
  • Biochemistry


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