Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim; Junghyo Yoon; Jae Yeong Byun; Hyunho Kim; Sewoon Han; Junghyun Kim; Jeong Hoon Lee; Han Sang Jo; Seok Chung

doi:10.3390/s21041366

Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Jaehoon Kim, Junghyo Yoon, Jae Yeong Byun, Hyunho Kim, Sewoon Han, Junghyun Kim, Jeong Hoon Lee, Han Sang Jo, Seok Chung

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

Original language	English
Article number	1366
Pages (from-to)	1-19
Number of pages	19
Journal	Sensors (Switzerland)
Volume	21
Issue number	4
DOIs	https://doi.org/10.3390/s21041366
Publication status	Published - 2021 Feb 2

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Blood plasma extraction
Microfluidics
Point-of-care testing

ASJC Scopus subject areas

Analytical Chemistry
Information Systems
Instrumentation
Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering
Biochemistry

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10.3390/s21041366

Cite this

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abstract = "Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.",

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AU - Kim, Jaehoon

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AU - Han, Sewoon

AU - Kim, Junghyun

AU - Lee, Jeong Hoon

AU - Jo, Han Sang

AU - Chung, Seok

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AB - Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μl of extracted plasma with a high extraction yield (~45%) in 16 min.

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Nano-interstice driven powerless blood plasma extraction in a membrane filter integrated microfluidic device

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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