Nano-structured chitosan self-aggregates as a drug delivery carrier

Min Su Bae; Ick Chan Kwon; Seo Young Jeong; Kuen Yong Lee

Nano-structured chitosan self-aggregates as a drug delivery carrier

Min Su Bae, Ick Chan Kwon, Seo Young Jeong, Kuen Yong Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Colloidal delivery systems including polymeric self-aggregates have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. Various characteristics of self-aggregates prepared from deoxycholic acid-modified chitosan were investigated by fluorescence spectroscopic and dynamic light scattering methods, and found to be controlled by the degree of substitution of hydrophobic groups, and pH and ionic strength of the medium. Chitosan self-aggregates can form complexes with plasmid DNA, and can be used to transfect COS-1 cells in vitro. Adriamycin can be also entrapped into chitosan self-aggregates and released in a sustained manner in vitro. These self-aggregates may find potential applications as a delivery vehicle of genes and anti-cancer drugs.

Original language	English
Title of host publication	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
Editors	M. Laudon, B. Romanowicz
Pages	164-167
Number of pages	4
Publication status	Published - 2005
Event	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States Duration: 2005 May 8 → 2005 May 12

Publication series

Name	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Other

Other	2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
Country/Territory	United States
City	Anaheim, CA
Period	05/5/8 → 05/5/12

Keywords

Adriamycin
Chitosan
DNA
Self-aggregates

ASJC Scopus subject areas

General Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Bae, M. S., Kwon, I. C., Jeong, S. Y., & Lee, K. Y. (2005). Nano-structured chitosan self-aggregates as a drug delivery carrier. In M. Laudon, & B. Romanowicz (Eds.), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings (pp. 164-167). (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

Nano-structured chitosan self-aggregates as a drug delivery carrier. / Bae, Min Su; Kwon, Ick Chan; Jeong, Seo Young et al.
2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. ed. / M. Laudon; B. Romanowicz. 2005. p. 164-167 (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bae, MS, Kwon, IC, Jeong, SY & Lee, KY 2005, Nano-structured chitosan self-aggregates as a drug delivery carrier. in M Laudon & B Romanowicz (eds), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings, pp. 164-167, 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005, Anaheim, CA, United States, 05/5/8.

Bae, Min Su ; Kwon, Ick Chan ; Jeong, Seo Young et al. / Nano-structured chitosan self-aggregates as a drug delivery carrier. 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings. editor / M. Laudon ; B. Romanowicz. 2005. pp. 164-167 (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).

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Nano-structured chitosan self-aggregates as a drug delivery carrier

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

UN SDGs

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