Nano-structured chitosan self-aggregates as a drug delivery carrier

Min Su Bae, Ick Chan Kwon, Seo Young Jeong, Kuen Yong Lee

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    Colloidal delivery systems including polymeric self-aggregates have been widely investigated to date, as these formulations may reduce unwanted side effects and may improve the therapeutic effects. Various characteristics of self-aggregates prepared from deoxycholic acid-modified chitosan were investigated by fluorescence spectroscopic and dynamic light scattering methods, and found to be controlled by the degree of substitution of hydrophobic groups, and pH and ionic strength of the medium. Chitosan self-aggregates can form complexes with plasmid DNA, and can be used to transfect COS-1 cells in vitro. Adriamycin can be also entrapped into chitosan self-aggregates and released in a sustained manner in vitro. These self-aggregates may find potential applications as a delivery vehicle of genes and anti-cancer drugs.

    Original languageEnglish
    Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
    EditorsM. Laudon, B. Romanowicz
    Pages164-167
    Number of pages4
    Publication statusPublished - 2005
    Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
    Duration: 2005 May 82005 May 12

    Publication series

    Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

    Other

    Other2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
    Country/TerritoryUnited States
    CityAnaheim, CA
    Period05/5/805/5/12

    Keywords

    • Adriamycin
    • Chitosan
    • DNA
    • Self-aggregates

    ASJC Scopus subject areas

    • General Engineering

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