Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Ranjith Kumar Kankala, Ya Hui Han, Jongbeom Na, Chia Hung Lee, Ziqi Sun, Shi Bin Wang, Tatsuo Kimura, Yong Sik Ok, Yusuke Yamauchi, Ai Zheng Chen, Kevin C.W. Wu

Research output: Contribution to journalReview articlepeer-review

254 Citations (Scopus)


Mesoporous silica nanoparticles (MSNs), one of the important porous materials, have garnered interest owing to their highly attractive physicochemical features and advantageous morphological attributes. They are of particular importance for use in diverse fields including, but not limited to, adsorption, catalysis, and medicine. Despite their intrinsic stable siliceous frameworks, excellent mechanical strength, and optimal morphological attributes, pristine MSNs suffer from poor drug loading efficiency, as well as compatibility and degradability issues for therapeutic, diagnostic, and tissue engineering purposes. Collectively, the desirable and beneficial properties of MSNs have been harnessed by modifying the surface of the siliceous frameworks through incorporating supramolecular assemblies and various metal species, and through incorporating supramolecular assemblies and various metal species and their conjugates. Substantial advancements of these innovative colloidal inorganic nanocontainers drive researchers in promoting them toward innovative applications like stimuli (light/ultrasound/magnetic)-responsive delivery-associated therapies with exceptional performance in vivo. Here, a brief overview of the fabrication of siliceous frameworks, along with discussions on the significant advances in engineering of MSNs, is provided. The scope of the advancement in terms of structural and physicochemical attributes and their effects on biomedical applications with a particular focus on recent studies is emphasized. Finally, interesting perspectives are recapitulated, along with the scope toward clinical translation.

Original languageEnglish
Article number1907035
JournalAdvanced Materials
Issue number23
Publication statusPublished - 2020 Jun 1


  • mesoporous silica nanoparticles
  • metal shielding
  • nanomaterials
  • surface modification

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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