Abstract
In this paper, we report the nanomechanical motion of a microcantilever due to the conformational transitions of DNA molecules that are functionalized on the surface of a microcantilever. In particular, the conformational transitions of DNA molecules can be induced by the change of ionic concentrations, which results in the bending deflection motion of a microcantilever. It is shown that a cantilever-DNA hybrid system is able to sense and detect the chemical environment changes such as pH change and/or ionic concentration change, and also that microscale device such as microcantilever can be actuated using molecular conformational changes. Our study provides a new insight into the development of a novel nano-bio-hybrid system based on microdevice coupled with molecular motors for chemical sensing as well as chemical-driven actuation.
Original language | English |
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Pages (from-to) | 117-122 |
Number of pages | 6 |
Journal | BioNanoScience |
Volume | 1 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2011 Dec |
Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) under Grant No. NRF-2010-0009428, NRF-2010-0027238, NRF-2010-0011832.
Keywords
- Bending deflection motion
- Conformational change
- DNA motor
- Ion sensing
- Microcantilever
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering