Nanoneedle transistor-based sensors for the selective detection of intracellular calcium ions

Donghee Son, Sung Young Park, Byeongju Kim, Jun Tae Koh, Tae Hyun Kim, Sangmin An, Doyoung Jang, Gyu Tae Kim, Wonho Jhe, Seunghun Hong

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


We developed a nanoneedle transistor-based sensor (NTS) for the selective detection of calcium ions inside a living cell. In this work, a single-walled carbon nanotube-based field effect transistor (swCNT-FET) was first fabricated at the end of a glass nanopipette and functionalized with Fluo-4-AM probe dye. The selective binding of calcium ions onto the dye molecules altered the charge state of the dye molecules, resulting in the change of the source-drain current of the swCNT-FET as well as the fluorescence intensity from the dye. We demonstrated the electrical and fluorescence detection of the concentration change of intracellular calcium ions inside a HeLa cell using the NTS.

Original languageEnglish
Pages (from-to)3888-3895
Number of pages8
JournalACS nano
Issue number5
Publication statusPublished - 2011 May 24


  • Carbon nanotube
  • Field effect transistor
  • Fluo-4-AM dye
  • Intracellular calcium ion
  • Nanoneedle transistor-based sensor
  • Real-time sensor

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy


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