Nanoparticles targeting innate immune cells in tumor microenvironment

Hochung Jang; Eun Hye Kim; Sung Gil Chi; Sun Hwa Kim; Yoosoo Yang

doi:10.3390/ijms221810009

Nanoparticles targeting innate immune cells in tumor microenvironment

Hochung Jang, Eun Hye Kim, Sung Gil Chi, Sun Hwa Kim, Yoosoo Yang

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.

Original language	English
Article number	10009
Journal	International journal of molecular sciences
Volume	22
Issue number	18
DOIs	https://doi.org/10.3390/ijms221810009
Publication status	Published - 2021 Sept

Bibliographical note

Funding Information:
Funding: This work was supported by the Intramural Research Program of KIST.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer therapy
Innate immune cells
Nanoparticles
Tumor microenvironment

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms221810009

Cite this

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title = "Nanoparticles targeting innate immune cells in tumor microenvironment",

abstract = "A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.",

keywords = "Cancer therapy, Innate immune cells, Nanoparticles, Tumor microenvironment",

author = "Hochung Jang and Kim, {Eun Hye} and Chi, {Sung Gil} and Kim, {Sun Hwa} and Yoosoo Yang",

note = "Funding Information: Funding: This work was supported by the Intramural Research Program of KIST. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/ijms221810009",

language = "English",

volume = "22",

journal = "International journal of molecular sciences",

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AU - Jang, Hochung

AU - Kim, Eun Hye

AU - Chi, Sung Gil

AU - Kim, Sun Hwa

AU - Yang, Yoosoo

PY - 2021/9

Y1 - 2021/9

N2 - A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.

AB - A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.

KW - Cancer therapy

KW - Innate immune cells

KW - Nanoparticles

KW - Tumor microenvironment

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DO - 10.3390/ijms221810009

M3 - Review article

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SN - 1661-6596

VL - 22

JO - International journal of molecular sciences

JF - International journal of molecular sciences

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ER -

Nanoparticles targeting innate immune cells in tumor microenvironment

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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