Nanoparticles targeting innate immune cells in tumor microenvironment

Hochung Jang, Eun Hye Kim, Sung Gil Chi, Sun Hwa Kim, Yoosoo Yang

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.

Original languageEnglish
Article number10009
JournalInternational journal of molecular sciences
Issue number18
Publication statusPublished - 2021 Sept

Bibliographical note

Funding Information:
Funding: This work was supported by the Intramural Research Program of KIST.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cancer therapy
  • Innate immune cells
  • Nanoparticles
  • Tumor microenvironment

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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