Nanophotosensitizers toward advanced photodynamic therapy of Cancer

Chang Keun Lim; Jeongyun Heo; Seunghoon Shin; Keunsoo Jeong; Young Hun Seo; Woo Dong Jang; Chong Rae Park; Soo Young Park; Sehoon Kim; Ick Chan Kwon

doi:10.1016/j.canlet.2012.09.012

Nanophotosensitizers toward advanced photodynamic therapy of Cancer

Chang Keun Lim, Jeongyun Heo, Seunghoon Shin, Keunsoo Jeong, Young Hun Seo, Woo Dong Jang, Chong Rae Park, Soo Young Park, Sehoon Kim, Ick Chan Kwon

Research output: Contribution to journal › Review article › peer-review

267 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy.

Original language	English
Pages (from-to)	176-187
Number of pages	12
Journal	Cancer letters
Volume	334
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.09.012
Publication status	Published - 2013 Jul 1

Bibliographical note

Funding Information:
This work was supported by grants from the Korea Ministry of Education, Science and Technology (MEST) (Nos. 2012-0001082 and 2012-0006061) and by the Intramural Research Program of KIST.

Keywords

Nanomedicine
Nanotherapeutics
Photodynamic therapy
Photosensitizer

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.09.012

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title = "Nanophotosensitizers toward advanced photodynamic therapy of Cancer",

abstract = "Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy.",

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author = "Lim, {Chang Keun} and Jeongyun Heo and Seunghoon Shin and Keunsoo Jeong and Seo, {Young Hun} and Jang, {Woo Dong} and Park, {Chong Rae} and Park, {Soo Young} and Sehoon Kim and Kwon, {Ick Chan}",

note = "Funding Information: This work was supported by grants from the Korea Ministry of Education, Science and Technology (MEST) (Nos. 2012-0001082 and 2012-0006061) and by the Intramural Research Program of KIST.",

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doi = "10.1016/j.canlet.2012.09.012",

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AU - Lim, Chang Keun

AU - Heo, Jeongyun

AU - Shin, Seunghoon

AU - Jeong, Keunsoo

AU - Seo, Young Hun

AU - Jang, Woo Dong

AU - Park, Chong Rae

AU - Park, Soo Young

AU - Kim, Sehoon

AU - Kwon, Ick Chan

N1 - Funding Information: This work was supported by grants from the Korea Ministry of Education, Science and Technology (MEST) (Nos. 2012-0001082 and 2012-0006061) and by the Intramural Research Program of KIST.

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N2 - Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy.

AB - Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT: (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy.

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KW - Photosensitizer

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Nanophotosensitizers toward advanced photodynamic therapy of Cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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