Nanoprobes for biomedical imaging in living systems

Heebeom Koo; Myung Sook Huh; Ju Hee Ryu; Dong Eun Lee; In Cheol Sun; Kuiwon Choi; Kwangmeyung Kim; Ick Chan Kwon

doi:10.1016/j.nantod.2011.02.007

Nanoprobes for biomedical imaging in living systems

Heebeom Koo
, Myung Sook Huh
, Ju Hee Ryu
, Dong Eun Lee
, In Cheol Sun
, Kuiwon Choi
, Kwangmeyung Kim
, Ick Chan Kwon

Research output: Contribution to journal › Review article › peer-review

152 Citations (Scopus)

Abstract

Recent progress in bio and nanotechnology enables the development of various nanoprobes for biomedical imaging. The detection and imaging of specific changes in biological microenvironments play key roles in many fields such as biological mechanism study, drug screening, diagnosis of many diseases, and monitoring of therapeutic responses. Especially to obtain fine images in living systems, there are many requirements such as stability in complex condition, efficient accumulation in target site, and high sensitivity to the target molecule. For this purpose, many researchers have developed a number of nano-size probes sensitive to the external changes which are valuable from biomedical point of view. Herein, we will review the on-going challenges of developing novel nanoprobes to detect chemical or biological changes such as enzyme, oxygen, and pH, and applying them to biomedical imaging in living systems.

Original language	English
Pages (from-to)	204-220
Number of pages	17
Journal	Nano Today
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.nantod.2011.02.007
Publication status	Published - 2011 Apr

Bibliographical note

Funding Information:
This research was supported by Real-Time Molecular Imaging Project, M.D.-Ph.D. Program (2010-0019863, 2010-0019864) of MEST, Fusion Technology Project (2009-0081876) of MEST, and National R&D Program for Cancer Control of Ministry for Health and Welfare from Republic of Korea (1020260).

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

Diagnosis
Imaging
Nanoparticle
Nanoprobe
Nanotechnology
Sensor

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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10.1016/j.nantod.2011.02.007

Cite this

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title = "Nanoprobes for biomedical imaging in living systems",

abstract = "Recent progress in bio and nanotechnology enables the development of various nanoprobes for biomedical imaging. The detection and imaging of specific changes in biological microenvironments play key roles in many fields such as biological mechanism study, drug screening, diagnosis of many diseases, and monitoring of therapeutic responses. Especially to obtain fine images in living systems, there are many requirements such as stability in complex condition, efficient accumulation in target site, and high sensitivity to the target molecule. For this purpose, many researchers have developed a number of nano-size probes sensitive to the external changes which are valuable from biomedical point of view. Herein, we will review the on-going challenges of developing novel nanoprobes to detect chemical or biological changes such as enzyme, oxygen, and pH, and applying them to biomedical imaging in living systems.",

keywords = "Diagnosis, Imaging, Nanoparticle, Nanoprobe, Nanotechnology, Sensor",

author = "Heebeom Koo and Huh, \{Myung Sook\} and Ryu, \{Ju Hee\} and Lee, \{Dong Eun\} and Sun, \{In Cheol\} and Kuiwon Choi and Kwangmeyung Kim and Kwon, \{Ick Chan\}",

note = "Funding Information: This research was supported by Real-Time Molecular Imaging Project, M.D.-Ph.D. Program (2010-0019863, 2010-0019864) of MEST, Fusion Technology Project (2009-0081876) of MEST, and National R\&D Program for Cancer Control of Ministry for Health and Welfare from Republic of Korea (1020260). Copyright: Copyright 2011 Elsevier B.V., All rights reserved.",

year = "2011",

month = apr,

doi = "10.1016/j.nantod.2011.02.007",

language = "English",

volume = "6",

pages = "204--220",

journal = "Nano Today",

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AU - Koo, Heebeom

AU - Huh, Myung Sook

AU - Ryu, Ju Hee

AU - Lee, Dong Eun

AU - Sun, In Cheol

AU - Choi, Kuiwon

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

N1 - Funding Information: This research was supported by Real-Time Molecular Imaging Project, M.D.-Ph.D. Program (2010-0019863, 2010-0019864) of MEST, Fusion Technology Project (2009-0081876) of MEST, and National R&D Program for Cancer Control of Ministry for Health and Welfare from Republic of Korea (1020260). Copyright: Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2011/4

Y1 - 2011/4

N2 - Recent progress in bio and nanotechnology enables the development of various nanoprobes for biomedical imaging. The detection and imaging of specific changes in biological microenvironments play key roles in many fields such as biological mechanism study, drug screening, diagnosis of many diseases, and monitoring of therapeutic responses. Especially to obtain fine images in living systems, there are many requirements such as stability in complex condition, efficient accumulation in target site, and high sensitivity to the target molecule. For this purpose, many researchers have developed a number of nano-size probes sensitive to the external changes which are valuable from biomedical point of view. Herein, we will review the on-going challenges of developing novel nanoprobes to detect chemical or biological changes such as enzyme, oxygen, and pH, and applying them to biomedical imaging in living systems.

AB - Recent progress in bio and nanotechnology enables the development of various nanoprobes for biomedical imaging. The detection and imaging of specific changes in biological microenvironments play key roles in many fields such as biological mechanism study, drug screening, diagnosis of many diseases, and monitoring of therapeutic responses. Especially to obtain fine images in living systems, there are many requirements such as stability in complex condition, efficient accumulation in target site, and high sensitivity to the target molecule. For this purpose, many researchers have developed a number of nano-size probes sensitive to the external changes which are valuable from biomedical point of view. Herein, we will review the on-going challenges of developing novel nanoprobes to detect chemical or biological changes such as enzyme, oxygen, and pH, and applying them to biomedical imaging in living systems.

KW - Diagnosis

KW - Imaging

KW - Nanoparticle

KW - Nanoprobe

KW - Nanotechnology

KW - Sensor

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U2 - 10.1016/j.nantod.2011.02.007

DO - 10.1016/j.nantod.2011.02.007

M3 - Review article

AN - SCOPUS:79954414852

SN - 1748-0132

VL - 6

SP - 204

EP - 220

JO - Nano Today

JF - Nano Today

IS - 2

ER -

Nanoprobes for biomedical imaging in living systems

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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