Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Nem Singh, Subin Son, Jusung An, Ilwha Kim, Minhyeok Choi, Na Kong, Wei Tao, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)


Finding a personalized nano theranostics solution, a nanomedicine for cancer diagnosis and therapy, is among the top challenges of current medicinal science. Porous organic polymers (POPs) are permanent porous organic materials prepared by linking relatively rigid multidimensional organic building blocks. POP nanoparticles have a remarkable advantage for cancer theranostics owing to their specific physicochemical characteristics such as high surface area, convincing pore size engineering, stimuli-responsive degradability, negligible toxicity, open covalent post-synthesis modification possibilities etc. POPs have crystalline and non-crystalline characteristics; crystalline POPs are popularly known as covalent organic frameworks (COFs), and have shown potential application across research areas in science. The early research and development on theranostics applications of nanoscale POPs has shown tremendous future potential for clinical translation. This tutorial review highlights the recently developed promising applications of nPOPs in drug loading, targeted delivery, endogenous and exogenous stimuli-responsive release, cancer imaging and combination therapy, regardless of their crystalline and poorly crystalline properties. The review will provide a platform for the future development and clinical translation of nPOPs by solving fundamental challenges of cancer nanomedicines in drug loading efficiency, size-optimization, biocompatibility, dispersibility and cell uptake ability.

Original languageEnglish
Pages (from-to)12883-12896
Number of pages14
JournalChemical Society Reviews
Issue number23
Publication statusPublished - 2021 Dec 7

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI Project No. 2018R1A3B1052702, and NRF-2019M3E5D1A01068998, J. S. K.). W. T. was supported by the U.S. METAvivor Early Career Investigator Award (Grant No. 2018A020560).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Chemistry(all)


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