Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

Shen Li; Xiaocong Sun; Yang Li; Feng Liu; Jun Ma; Ling Tong; Guochen Su; Jing Xu; Yasushi Ohizumi; Dongho Lee; Yuanqiang Guo

doi:10.1016/j.bmcl.2016.11.044

Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

Shen Li, Xiaocong Sun, Yang Li, Feng Liu, Jun Ma, Ling Tong, Guochen Su, Jing Xu, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.

Original language	English
Pages (from-to)	670-674
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2016.11.044
Publication status	Published - 2017

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007).

Keywords

9,10-seco-Abietane diterpenoid
Callicarpa kwangtungensis
Molecular docking
NO inhibitory activities
Terpenoids
iNOS

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2016.11.044

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abstract = "A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.",

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author = "Shen Li and Xiaocong Sun and Yang Li and Feng Liu and Jun Ma and Ling Tong and Guochen Su and Jing Xu and Yasushi Ohizumi and Dongho Lee and Yuanqiang Guo",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007).",

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doi = "10.1016/j.bmcl.2016.11.044",

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AU - Liu, Feng

AU - Ma, Jun

AU - Tong, Ling

AU - Su, Guochen

AU - Xu, Jing

AU - Ohizumi, Yasushi

AU - Lee, Dongho

AU - Guo, Yuanqiang

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 21372125), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007).

PY - 2017

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Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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