Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Eung Tae Yeon; Jin Woo Lee; Chul Lee; Qinghao Jin; Hari Jang; Dongho Lee; Jong Seog Ahn; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.5b00126

Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Eung Tae Yeon, Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Jong Seog Ahn, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC₅₀ values ranging from 20.2 to 35.6 M.

Original language	English
Pages (from-to)	2292-2296
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00126
Publication status	Published - 2015 Sept 25

Bibliographical note

Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00126

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title = "Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production",

abstract = "Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 M.",

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doi = "10.1021/acs.jnatprod.5b00126",

language = "English",

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AU - Lee, Chul

AU - Jin, Qinghao

AU - Jang, Hari

AU - Lee, Dongho

AU - Ahn, Jong Seog

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Abstract

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