Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Eung Tae Yeon; Jin Woo Lee; Chul Lee; Qinghao Jin; Hari Jang; Dongho Lee; Jong Seog Ahn; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.5b00126

Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Eung Tae Yeon
, Jin Woo Lee
, Chul Lee
, Qinghao Jin
, Hari Jang
, Dongho Lee
, Jong Seog Ahn
, Jin Tae Hong
, Youngsoo Kim
, Mi Kyeong Lee
, Bang Yeon Hwang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC₅₀ values ranging from 20.2 to 35.6 M.

Original language	English
Pages (from-to)	2292-2296
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00126
Publication status	Published - 2015 Sept 25

Bibliographical note

Publisher Copyright:
© 2015 The American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00126

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title = "Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production",

abstract = "Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 M.",

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note = "Publisher Copyright: {\textcopyright} 2015 The American Chemical Society and American Society of Pharmacognosy.",

year = "2015",

month = sep,

day = "25",

doi = "10.1021/acs.jnatprod.5b00126",

language = "English",

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journal = "Journal of Natural Products",

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AU - Yeon, Eung Tae

AU - Lee, Jin Woo

AU - Lee, Chul

AU - Jin, Qinghao

AU - Jang, Hari

AU - Lee, Dongho

AU - Ahn, Jong Seog

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2015/9/25

Y1 - 2015/9/25

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IS - 9

ER -

Neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production

Abstract

Bibliographical note

ASJC Scopus subject areas

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