Neuregulin-1 prevents amyloid β-induced impairment of long-term potentiation in hippocampal slices via ErbB4

Sun Seek Min, Jihua An, Ji Hye Lee, Geun Hee Seol, Jae Hyeung Im, Hye Sun Kim, Tai Kyoung Baik, Ran Sook Woo

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35 Citations (Scopus)


Neuregulin-1 (NRG1) participates in numerous neurodevelopmental processes and plasticity of the brain. Despite this, little is known about its role in Alzheimer's disease (AD). Amyloid β (Aβ) peptide is generally believed to play a critical role in the pathogenesis of AD. The present study examined the effect of synthetic Aβ 1-42 peptides on long-term potentiation (LTP) in the CA1 region of mice hippocampal slices, a cellular model of learning and memory. We found that application of a test dose of Aβ 1-42 (200nM) significantly inhibited the development of LTP without affecting basal synaptic transmission. Pretreatment with NRG1 effectively prevented Aβ 1-42-induced impairment of LTP, an effect that was dose-dependent. This LTP-restoring action of NRG1 was almost completely abolished by blocking ErbB4, a key NRG1 receptor, suggesting that NRG1 acts through ErbB4 to exert its protective action on LTP. The present study thus provides the first demonstration that NRG1/ErbB4 protects against Aβ-induced hippocampal LTP impairment, suggesting that NRG1 may be a promising candidate for the treatment of early-stage AD.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2011 Nov 7

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Foundation of Korea ( NRF-2009-0074146 ) and the Korean Government ( KRF-2008-331-E00292 ). S.S. Min was supported by the Mid-career Researcher program through an NRF grant funded by the MEST ( 2009–0085840 ).


  • Alzheimer's disease
  • Amyloid beta peptide
  • ErbB4
  • Hippocampus
  • Long-term potentiation
  • Neuregulin

ASJC Scopus subject areas

  • General Neuroscience


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